SCHEMBL2353376

SCHEMBL2353376

C[C@H](OC(=O)CCC(=O)[O-])C(=O)O.[Na+]

nearest known ligand 0.43

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CA1 known ✓ P00915 3/20 0.43
CA2 known ✓ P00918 2/20 0.37
ELANE P08246 1/20 0.40
FFAR3 O14843 2/20 0.38
HDAC3 O15379 2/20 0.38
HDAC1 Q13547 2/20 0.38
HDAC2 Q92769 2/20 0.38
HDAC8 Q9BY41 2/20 0.38
BBOX1 O75936 2/20 0.35
LMNA P02545 2/20 0.33
MMP1 P03956 1/20 0.33
MMP2 P08253 1/20 0.33
MMP3 P08254 1/20 0.33
MMP9 P14780 1/20 0.33
MMP13 P45452 1/20 0.33
USP2 O75604 1/20 0.33
NFKB1 P19838 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7110445 0.87 LMNA (0.40) LMNAMMP1MMP2MMP3MMP9
SCHEMBL2608669 0.87 LMNA (0.40) LMNAMMP1MMP2MMP3MMP9
Acetic Acid SCHEMBL22769870 0.83 LMNA (0.38) FFAR3LMNAMMP1MMP2MMP3
SCHEMBL9817250 0.81 LMNA (0.50) LMNAMMP1MMP2MMP3MMP9
SCHEMBL935213 0.81 EGLN1 (0.45) FFAR3HDAC3HDAC1HDAC2HDAC8
SCHEMBL11411203 0.81 CA1 (0.41) CA1ELANEFFAR3HDAC3HDAC1
SCHEMBL18218913 0.79 ALDH1A1 (0.43) LMNAMMP1MMP2MMP3MMP9
SCHEMBL19107033 0.78 LMNA (0.34) LMNAMMP1MMP2MMP3MMP9
Potassium Ion SCHEMBL11403492 0.77 CA1 (0.38) CA1ELANEFFAR3HDAC3HDAC1
SCHEMBL18651161 0.77 ALDH1A1 (0.48) FFAR3HDAC3HDAC1HDAC2HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9926578-B2 Process for manufacturing butanediol PURAC BIOCHEM BV (NL) 2018-03-27 US disclosed
US-20160040194-A1 Process for manufacturing butanediol PURAC BIOCHEM BV (NL) 2016-02-11 US disclosed
US-9162961-B2 Process for manufacturing succinic acid PURAC BIOCHEM BV (NL) 2015-10-20 US disclosed
CN-102753514-B Process for manufacturing succinic acid PURAC BIOCHEM BV 2014-11-26 CN disclosed
EP-2360137-B1 Process for manufacturing succinic acid PURAC BIOCHEM BV (NL) 2013-08-07 EP disclosed
EP-2534124-A1 PROCESS FOR MANUFACTURING SUCCINIC ACID PURAC Biochem BV (NL) 2012-12-19 EP disclosed
US-20120316368-A1 PROCESS FOR MANUFACTURING SUCCINIC ACID PURAC BIOCHEM BV (NL) 2012-12-13 US disclosed
CN-102753514-A Process for manufacturing succinic acid PURAC BIOCHEM BV 2012-10-24 CN disclosed
EP-2360137-A1 Process for manufacturing succinic acid PURAC Biochem BV (NL) 2011-08-24 EP disclosed
WO-2011098598-A1 PROCESS FOR MANUFACTURING SUCCINIC ACID PURAC BIOCHEM BV (NL) 2011-08-18 WO disclosed