Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.44 |
| ▸ | CTSS | P25774 | 4/20 | 0.44 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.43 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 4/20 | 0.40 |
| ▸ | CTSB | P07858 | 3/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9364548 | 0.86 | CTSK (0.45) | CTSLCTSSSLC15A1CTSKCTSB | |
| SCHEMBL7476658 | 0.86 | SLC15A1 (0.46) | CTSLCTSSSLC15A1CTSKCTSB | |
| SCHEMBL9364447 | 0.81 | LNPEP (0.40) | CTSLCTSSSLC15A1LNPEPERAP2 | |
| SCHEMBL9365216 | 0.78 | CTSK (0.46) | CTSLCTSSCTSKCTSBSLC1A3 | |
| SCHEMBL9011869 | 0.74 | CTSL (0.49) | CTSLCTSSLNPEPCTSKCTSB | |
| SCHEMBL9364449 | 0.74 | SLC15A1 (0.45) | SLC15A1 | |
| SCHEMBL9364872 | 0.73 | NAAA (0.38) | CTSLCTSSSLC15A1LNPEPERAP2 | |
| SCHEMBL5501379 | 0.71 | CTSL (0.61) | CTSLCTSSCTSKCTSB | |
| SCHEMBL7266217 | 0.71 | ALDH1A1 (0.52) | CTSLCTSSLNPEPERAP2SLC1A3 | |
| SCHEMBL7266221 | 0.71 | ALDH1A1 (0.52) | CTSLCTSSLNPEPERAP2SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538396-A4 | — | — | 1994-04-13 | — | — | EP | disclosed |
| EP-0538396-A1 | INHIBITORS OF RETROVIRAL PROTEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000948-A1 | INHIBITORS OF RETROVIRAL PROTEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |