Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 2/20 | 0.30 |
| ▸ | GABRD | O14764 | 2/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butadiene SCHEMBL501645 | 0.90 | ALDH1A1 (0.40) | ALDH1A1PTGS1LMNAAKR1C3 | |
| Butadiene SCHEMBL464974 | 0.90 | ALDH1A1 (0.40) | ALDH1A1PTGS1LMNAAKR1C3 | |
| Butadiene SCHEMBL464883 | 0.90 | ALDH1A1 (0.40) | ALDH1A1PTGS1LMNAAKR1C3 | |
| Fumaric Acid SCHEMBL3815775 | 0.90 | TSHR (0.53) | TSHRTP53EGLN1EGLN3ALDH1A1 | |
| Butadiene SCHEMBL17699118 | 0.85 | ALDH1A1 (0.36) | ALDH1A1PTGS1LMNAAKR1C3 | |
| Butadiene SCHEMBL27656929 | 0.83 | ACHE (0.35) | TSHRALDH1A1ALOX15TDP1PTGS1 | |
| Acrylic Acid SCHEMBL357769 | 0.82 | LMNA (0.56) | TSHRTP53ALDH1A1ALOX15HSD17B10 | |
| Acrylic Acid SCHEMBL1739613 | 0.82 | LMNA (0.56) | TSHRTP53ALDH1A1ALOX15HSD17B10 | |
| Propene SCHEMBL7932633 | 0.82 | ALDH1A1 (0.42) | TSHRTP53ALDH1A1HSD17B10TDP1 | |
| Crotonic Acid SCHEMBL16178256 | 0.80 | TSHR (0.40) | TSHRTP53EGLN1EGLN3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360780-A | Image-receiving sheet for thermal transfer printing with a layer containing aggregates of fine particles of thermoplastic resin | KANZAKI PAPER MANUFACTURING CO., LTD. (JP) | 1994-11-01 | — | — | US | disclosed |