Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL942894 | 0.85 | KMT2A (0.53) | ALDH1A1MAPTKDM4EUSP2HTT | |
| SCHEMBL6226972 | 0.85 | HDAC1 (0.44) | ALDH1A1MAPTKDM4EAGTR1HTT | |
| SCHEMBL28756705 | 0.82 | L3MBTL1 (0.47) | MAPTKMT2AMEN1TDP1NPC1 | |
| SCHEMBL17183945 | 0.79 | L3MBTL1 (0.38) | ALDH1A1MAPTKMT2AMEN1TDP1 | |
| SCHEMBL28017685 | 0.73 | ALDH1A1 (0.53) | ALDH1A1MAPTKDM4EAGTR1USP2 | |
| SCHEMBL5604152 | 0.73 | MEP1B (0.46) | SMN1; SMN2RAB9A | |
| SCHEMBL12559833 | 0.72 | MAPT (0.52) | ALDH1A1MAPTKDM4EAGTR1USP2 | |
| SCHEMBL11452194 | 0.72 | AKR1B1 (0.41) | TDP1HPGDL3MBTL1CYP2C19 | |
| SCHEMBL11288690 | 0.71 | GSK3B (0.62) | ALDH1A1MAPTKDM4EAGTR1USP2 | |
| SCHEMBL11890414 | 0.71 | ALDH1A1 (0.44) | ALDH1A1MAPTKDM4EAGTR1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318782-B2 | Mitotic kinesin inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2012-11-27 | — | — | US | disclosed |
| EP-2327702-B1 | Mitotic kinesin inhibitor | KYOWA HAKKO KIRIN CO LTD (JP) | 2012-08-29 | — | — | EP | disclosed |
| EP-1616866-B1 | M-STAGE KINESIN INHIBITOR | KYOWA HAKKO KIRIN CO LTD (JP) | 2011-12-14 | — | — | EP | disclosed |
| US-20110275827-A1 | Mitotic Kinesin Inhibitor | FUJIFILM CORPORATION (JP) | 2011-11-10 | — | — | US | disclosed |
| EP-2327702-A1 | Mitotic kinesin inhibitor | Kyowa Hakko Kirin Co., Ltd. (JP) | 2011-06-01 | — | — | EP | disclosed |
| US-20110004000-A1 | Mitotic Kinesin Inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-01-06 | — | — | US | disclosed |
| US-7851635-B2 | Mitotic kinesin inhibitor | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-12-14 | — | — | US | disclosed |
| US-20070276017-A1 | Thiadiazoline Derivative | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2007-11-29 | — | — | US | disclosed |
| US-20070155804-A1 | Mitotic kinesin inhibitor | KYOWA HAKKO KOGYO CO., LTD. OF TOKYO, JAPAN FUJI PHOTO FILM CO., LTD. KANAGAWA, JAPAN | 2007-07-05 | — | — | US | disclosed |
| US-20070112044-A1 | Thiadiazoline derivative | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-05-17 | — | — | US | disclosed |
| EP-1671957-A1 | THIADIAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-06-21 | — | — | EP | disclosed |
| EP-1632484-A1 | THIADIAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-03-08 | — | — | EP | disclosed |
| EP-1616866-A1 | M-STAGE KINESIN INHIBITOR | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-01-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155804-A1 | Mitotic kinesin inhibitor | KIF15, KIF5A, KIF5B | ALDH1A1 2889/4885MAPT 254/4885KDM4E 1120/4885 |
| US-20110004000-A1 | Mitotic Kinesin Inhibitor | KIF15, KIF5A, KIF5B | ALDH1A1 2889/4885MAPT 254/4885KDM4E 1120/4885 |
| US-20070276017-A1 | Thiadiazoline Derivative | BRD7, NR3C2, NR5A2 | ALDH1A1 1571/4885MAPT 3490/4885KDM4E 3163/4885 |
| US-20070112044-A1 | Thiadiazoline derivative | TLK2, TLK1, BRWD1 | ALDH1A1 278/4885MAPT 4054/4885KDM4E 2739/4885 |
| US-20110275827-A1 | Mitotic Kinesin Inhibitor | KIF15, KIF5A, KIF5B | ALDH1A1 2889/4885MAPT 254/4885KDM4E 1120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.