Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.43 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9411459 | 1.00 | ACHE (0.45) | ACHEBCHEMEN1KMT2AHRH1 | |
| SCHEMBL9411434 | 0.94 | MAOA (0.46) | ACHEMEN1KMT2AHRH1MAOB | |
| Fumaric Acid SCHEMBL9411356 | 0.93 | ACHE (0.45) | ACHEBCHEMEN1KMT2AHRH1 | |
| Fumaric Acid SCHEMBL9411360 | 0.93 | ACHE (0.45) | ACHEBCHEMEN1KMT2AHRH1 | |
| SCHEMBL9411236 | 0.88 | MAOA (0.45) | ACHEMEN1KMT2AHRH1MAOB | |
| SCHEMBL9411206 | 0.86 | ACHE (0.50) | ACHEMEN1KMT2AHRH1MAOB | |
| SCHEMBL9411647 | 0.85 | ACHE (0.53) | ACHEBCHEMEN1KMT2AMAOB | |
| Fumaric Acid SCHEMBL9411594 | 0.85 | OPRM1 (0.39) | ACHEBCHE | |
| Fumaric Acid SCHEMBL9411592 | 0.85 | OPRM1 (0.39) | ACHEBCHE | |
| SCHEMBL9411209 | 0.82 | DRD2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0602242-A1 | BENZISOXAZOLE COMPOUND AND USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |