Sugi Predict

Sugi Predict / Compounds / SCHEMBL942176

SCHEMBL942176

SCHEMBL942176

C/C(=N\NC(N)=S)c1cccs1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CTSL P07711 3/20 1.00
▸ NPC1 O15118 4/20 0.64
▸ RAB9A P51151 4/20 0.64
▸ ALDH1A1 P00352 5/20 0.60
▸ LMNA P02545 2/20 0.60
▸ GAA P10253 2/20 0.60
▸ NPSR1 Q6W5P4 1/20 0.60
▸ SMN1; SMN2 Q16637 5/20 0.58
▸ HTT P42858 2/20 0.58
▸ TDP1 Q9NUW8 1/20 0.58
▸ CTSB P07858 1/20 0.56
▸ ALOX12 P18054 1/20 0.56
▸ L3MBTL1 Q9Y468 1/20 0.56
▸ ATM Q13315 1/20 0.56
▸ METTL3 Q86U44 1/20 0.56
▸ CYP1A2 P05177 1/20 0.54
▸ CYP2D6 P10635 1/20 0.54
▸ CYP2C9 P11712 1/20 0.54
▸ CYP2C19 P33261 1/20 0.54
▸ POLB P06746 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL942177 1.00 CTSL (1.00) CTSLNPC1RAB9AALDH1A1LMNA
SCHEMBL22875491 1.00 CTSL (1.00) CTSLNPC1RAB9AALDH1A1LMNA
SCHEMBL22056640 0.84 CTSL (0.72) CTSLNPC1RAB9AALDH1A1LMNA
SCHEMBL27596097 0.81 CTSL (0.68) CTSLNPC1RAB9AALDH1A1LMNA
SCHEMBL10692681 0.81 CTSL (0.68) CTSLNPC1RAB9AALDH1A1LMNA
SCHEMBL1520524 0.81 RAB9A (0.69) CTSLNPC1RAB9AALDH1A1LMNA
SCHEMBL1520519 0.81 RAB9A (0.69) CTSLNPC1RAB9AALDH1A1LMNA
SCHEMBL1520521 0.81 RAB9A (0.69) CTSLNPC1RAB9AALDH1A1LMNA
SCHEMBL9656096 0.78 RAB9A (0.76) CTSLNPC1RAB9AALDH1A1SMN1; SMN2
SCHEMBL9656092 0.78 RAB9A (0.76) CTSLNPC1RAB9AALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250059160-A1 Chemical Activators of Nicotinamide Mononucleotide adenylyltransferase 2 (NMNAT2) and Uses Thereof TSINGHUA UNIVERSITY (CN) 2025-02-20 — — US claimed
WO-2020107221-A1 CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF TSINGHUA UNIVERSITY (CN) 2020-06-04 — — WO claimed
US-20250059160-A1 Chemical Activators of Nicotinamide Mononucleotide adenylyltransferase 2 (NMNAT2) and Uses Thereof TSINGHUA UNIVERSITY (CN) 2025-02-20 — — US disclosed
CN-115197126-A Novel NMNAT enzyme agonist and preparation and application thereof 清华大学 2022-10-18 — — CN disclosed
WO-2020107221-A1 CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF TSINGHUA UNIVERSITY (CN) 2020-06-04 — — WO disclosed
WO-2020107221-A1 CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF TSINGHUA UNIVERSITY (CN) 2020-06-04 — — WO disclosed
EP-1454903-B9 Thiadiazoline derivatives for treating cancer KYOWA HAKKO KIRIN CO LTD (JP) 2011-10-05 — — EP disclosed
EP-2327702-A1 Mitotic kinesin inhibitor Kyowa Hakko Kirin Co., Ltd. (JP) 2011-06-01 — — EP disclosed
US-7902234-B2 Thiadiazoline derivative KYOWA HAKKO KIRIN CO., LTD. (JP) 2011-03-08 — — US disclosed
US-20110004000-A1 Mitotic Kinesin Inhibitor KYOWA HAKKO KIRIN CO., LTD. (JP) 2011-01-06 — — US disclosed
US-7851635-B2 Mitotic kinesin inhibitor KYOWA HAKKO KIRIN CO., LTD. (JP) 2010-12-14 — — US disclosed
US-7759371-B2 Thiadiazoline derivative Kyowa Hakko Kinn Co., Ltd. (JP) 2010-07-20 — — US disclosed
US-7425636-B2 Thiadiazoline derivative KYOWA HAKKO KOGYO CO., LTD. (JP) 2008-09-16 — — US disclosed
US-20080207706-A1 THIADIAZOLINE DERIVATIVE KYOWA HAKKO KOGYO CO., LTD (JP) 2008-08-28 — — US disclosed
EP-1847534-A2 Thiadiazoline derivative Kyowa Hakko Kogyo Co., Ltd (JP) 2007-10-24 — — EP disclosed
US-20070213380-A1 Thiadiazoline derivative KYOWA HAKKO KOGYO CO., LTD. (JP) 2007-09-13 — — US disclosed
US-20070155804-A1 Mitotic kinesin inhibitor KYOWA HAKKO KOGYO CO., LTD. OF TOKYO, JAPAN FUJI PHOTO FILM CO., LTD. KANAGAWA, JAPAN 2007-07-05 — — US disclosed
US-20060074113-A1 Thiadiazoline derivative KYOWA KIRIN CO., LTD. (JP) 2006-04-06 — — US disclosed
EP-1616866-A1 M-STAGE KINESIN INHIBITOR KYOWA HAKKO KOGYO CO., LTD. (JP) 2006-01-18 — — EP disclosed
EP-1454903-A1 THIADIAZOLINE DERIVATIVE KYOWA HAKKO KOGYO CO., LTD. (JP) 2004-09-08 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250059160-A1 Chemical Activators of Nicotinamide Mononucleotide adenylyltransferase 2 (NMNAT2) and Uses Thereof NAMPT, NNMT, NAPRT CTSL 3508/4885NPC1 381/4885RAB9A 1944/4885
US-20060074113-A1 Thiadiazoline derivative BRWD1, RB1, ARG2 CTSL 4237/4885NPC1 3361/4885RAB9A 710/4885
US-20070155804-A1 Mitotic kinesin inhibitor KIF15, KIF5A, KIF5B CTSL 4128/4885NPC1 2619/4885RAB9A 490/4885
US-20070213380-A1 Thiadiazoline derivative BRWD1, RB1, ARG2 CTSL 4237/4885NPC1 3361/4885RAB9A 710/4885
US-20110004000-A1 Mitotic Kinesin Inhibitor KIF15, KIF5A, KIF5B CTSL 4128/4885NPC1 2619/4885RAB9A 490/4885
US-20080207706-A1 THIADIAZOLINE DERIVATIVE BRWD1, RB1, ARG2 CTSL 4237/4885NPC1 3361/4885RAB9A 710/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.