SCHEMBL9433064

SCHEMBL9433064

O=C(Cl)c1sccc1S(=O)(=O)Cl

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.44
NPSR1 Q6W5P4 1/20 0.43
MEN1 O00255 1/20 0.41
CYP3A4 P08684 1/20 0.41
TSHR P16473 1/20 0.41
KMT2A Q03164 1/20 0.41
FABP4 P15090 5/20 0.37
FABP3 P05413 2/20 0.37
FABP2 P12104 2/20 0.37
FABP5 Q01469 2/20 0.37
MAPT P10636 3/20 0.35
TP53 P04637 1/20 0.35
GSK3B P49841 1/20 0.35
EDNRA P25101 3/20 0.34
KDM4E B2RXH2 1/20 0.34
ACLY P53396 1/20 0.33
THRB P10828 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9728565 0.84 LMNA (0.62) LMNANPSR1MEN1CYP3A4TSHR
Hydrochloric Acid SCHEMBL11485444 0.82 LMNA (0.61) LMNANPSR1MEN1CYP3A4TSHR
SCHEMBL4095819 0.78 LMNA (0.44) LMNANPSR1MEN1CYP3A4TSHR
SCHEMBL388034 0.78 MAPT (0.55) LMNAMEN1TSHRKMT2AMAPT
SCHEMBL8973307 0.74 PKM (0.45) LMNAMEN1CYP3A4TSHRKMT2A
SCHEMBL11484963 0.72 LMNA (0.36) LMNANPSR1MEN1CYP3A4TSHR
SCHEMBL27497626 0.72 KMT2A (0.57) LMNAMEN1CYP3A4TSHRKMT2A
SCHEMBL8973162 0.72 ALDH1A1 (0.42) LMNAMEN1TSHRKMT2AMAPT
SCHEMBL9571061 0.72 LMNA (0.34) LMNANPSR1MEN1CYP3A4TSHR
SCHEMBL9729949 0.71 CYP3A4 (0.44) LMNANPSR1MEN1CYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5342823-A Herbicides, plant growth regulators CIBA-GEIGY CORPORATION (US) 1994-08-30 US disclosed
US-4230873-A Thiophene derivatives HOFFMANN-LA ROCHE INC. (US) 1980-10-28 US disclosed
US-4224445-A ANTIINFLAMMATORY, ANALGESIC, ANTIRHEUMATIC HOFFMANN-LA ROCHE INC. (US) 1980-09-23 US disclosed
US-4177193-A ALKOXYCARBONYL, ALKYLAMINOSULFONYL-SUBSTITUTED THIOPHENE INTERMEDIATES FOR THE 4-HYDROXY-N-SUBSTITUTED-2H-THIENO(2,3-E)-1,2-THIAZINE-3-CARBOXAMIDE-1,1 -DIOXIDES; ANTIINFLAMMATORY, ANALGESIC HOFFMAN-LA ROCHE INC. (US) 1979-12-04 US disclosed
US-4175085-A ANTIINFLAMMATORY, ANALGESIC, ANTIRHEUMATIC HOFFMANN-LA ROCHE INC. (US) 1979-11-20 US disclosed
US-4134898-A ANTIINFLAMMATORY, ANALGESIC, ANTIRHEUMATIC HOFFMANN-LA ROCHE INC. (US) 1979-01-16 US disclosed
US-4090020-A ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS HOFFMANN-LA ROCHE INC. (US) 1978-05-16 US disclosed
US-4076709-A ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIRHEUMATIC AGENTS HOFFMANN-LA ROCHE INC. (US) 1978-02-28 US disclosed