SCHEMBL94336

SCHEMBL94336

COc1ccc(/C=C/CC(=O)OCCC(C)C)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.67
TDP1 Q9NUW8 1/20 0.67
GSK3B P49841 1/20 0.47
TAS1R3 Q7RTX0 5/20 0.46
TAS1R1 Q7RTX1 5/20 0.46
F3 P13726 2/20 0.45
GRIK1 P39086 1/20 0.44
GRIK2 Q13002 1/20 0.44
THRB P10828 1/20 0.44
ATM Q13315 1/20 0.44
CYP4F2 P78329 1/20 0.44
CYP4A11 Q02928 1/20 0.44
PPARA Q07869 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C19 P33261 1/20 0.43
HDAC3 O15379 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28307709 0.83 L3MBTL1 (0.55) LMNAGSK3BTAS1R3TAS1R1F3
Amiloxate SCHEMBL8095776 0.81 LMNA (1.00) LMNATDP1GSK3BTAS1R3TAS1R1
Amiloxate SCHEMBL15764 0.81 LMNA (1.00) LMNATDP1GSK3BTAS1R3TAS1R1
Amiloxate SCHEMBL15765 0.81 LMNA (1.00) LMNATDP1GSK3BTAS1R3TAS1R1
Amiloxate SCHEMBL2228053 0.81 LMNA (1.00) LMNATDP1GSK3BTAS1R3TAS1R1
Amiloxate SCHEMBL2228049 0.81 LMNA (1.00) LMNATDP1GSK3BTAS1R3TAS1R1
Amiloxate SCHEMBL31304727 0.80 LMNA (0.97) LMNATDP1GSK3BTAS1R3TAS1R1
Amiloxate SCHEMBL1768923 0.76 LMNA (0.90) LMNATDP1GSK3BTAS1R3TAS1R1
4-Methoxycinnamic Acid SCHEMBL27842260 0.76 TDP1 (0.63) LMNATDP1GSK3BTAS1R3TAS1R1
SCHEMBL8648429 0.76 GSK3B (0.61) LMNAGSK3BF3GRIK1GRIK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2425810-B1 Sunscreen compositions NEUTROGENA CORP (US) 2018-10-24 EP disclosed
EP-2275177-B1 Topical composition fluorescence detection JOHNSON & JOHNSON CONSUMER (US) 2015-01-21 EP disclosed
US-8236287-B2 Sunscreen compositions NEUTROGENA CORPORATION (US) 2012-08-07 US disclosed
US-20120058192-A1 SUNSCREEN COMPOSITIONS KENVUE BRANDS LLC 2012-03-08 US disclosed
EP-2425810-A2 Sunscreen compositions NEUTROGENA CORPORATION (US) 2012-03-07 EP disclosed
EP-2275177-A1 Topical composition fluorescence detection JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) 2011-01-19 EP disclosed
EP-2275176-A1 Topical sunscreen composition fluorescence detection JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) 2011-01-19 EP disclosed
WO-2010138710-A2 TOPICAL SKIN CARE COMPOSITIONS JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) 2010-12-02 WO disclosed
US-20100305064-A1 TOPICAL SKIN CARE COMPOSITIONS JOHNSON & JOHNSON CONSUMER COMPANIES, INC. 2010-12-02 US disclosed
US-20100303910-A1 TOPICAL SKIN CARE COMPOSITIONS JOHNSON & JOHNSON CONSUMER COMPANIES, INC. 2010-12-02 US disclosed
US-20050196347-A1 High lipid content sprayable emulsions BERILLOUET ANNE-SOPHIE (FR) 2005-09-08 US disclosed
EP-1537854-A1 High lipid content sprayable emulsions Johnson & Johnson Consumer France SAS (FR) 2005-06-08 EP disclosed
US-20050048856-A1 A dried porous or absorbent sheet of a nonwoven material where an aqueous and a lipid phase lipid phase of an oily nature have been applied; cleansing wipes for babies with improved skincare benefits in one single lotion; delivery of active ingredient; antisoilants for oil- and water-compatible soils JOHNSON & JOHNSON GMBH (DE) 2005-03-03 US disclosed
US-20050031847-A1 Products comprising a sheet and a lipid and aqueous phase MARTENS NICHOLAS (DE) 2005-02-10 US disclosed
EP-1408926-A1 DRY PRODUCTS COMPRISING A SHEET AND TWO PHASES JOHNSON & JOHNSON GmbH (DE) 2004-04-21 EP disclosed
EP-1408927-A1 PRODUCTS COMPRISING A SHEET AND A LIPID AND AQUEOUS PHASE Johnson and Johnson GmbH (DE) 2004-04-21 EP disclosed
WO-2003005982-A1 PRODUCTS COMPRISING A SHEET AND A LIPID AND AQUEOUS PHASE JOHNSON & JOHNSON GMBH (DE) 2003-01-23 WO disclosed
WO-2003005983-A1 DRY PRODUCTS COMPRISING A SHEET AND TWO PHASES JOHNSON & JOHNSON GMBH (DE) 2003-01-23 WO disclosed
EP-1275370-A1 Products comprising a sheet and a lipid and aqueous phase Johnson and Johnson GmbH (DE) 2003-01-15 EP disclosed
EP-1275371-A1 Dry products comprising a sheet and two phases Johnson and Johnson GmbH (DE) 2003-01-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100305064-A1 TOPICAL SKIN CARE COMPOSITIONS CUTA, POLR1C, IL33 LMNA 1095/4885TDP1 1429/4885GSK3B 807/4885
US-20100303910-A1 TOPICAL SKIN CARE COMPOSITIONS CUTA, DSG1, POLR1C LMNA 896/4885TDP1 1094/4885GSK3B 1537/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.