SCHEMBL94373

SCHEMBL94373

Nc1ccc(O)c(N)c1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 5/20 0.46
ALDH1A1 P00352 5/20 0.46
HSD17B10 Q99714 3/20 0.46
MAPK1 P28482 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
HPGD P15428 1/20 0.46
ALOX12 P18054 1/20 0.46
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
HDAC3 O15379 1/20 0.41
IDO1 P14902 1/20 0.41
EP300 Q09472 1/20 0.41
KAT2B Q92831 1/20 0.41
KAT8 Q9H7Z6 1/20 0.41
NCOR2 Q9Y618 1/20 0.41
CYP3A4 P08684 3/20 0.40
CSNK2A2 P19784 1/20 0.39
CSNK2B P67870 1/20 0.39
CSNK2A1 P68400 1/20 0.39
CSNK2A3 Q8NEV1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26099095 0.83 MAPK1 (0.50) ALOX15ALDH1A1HSD17B10MAPK1SMN1; SMN2
SCHEMBL1456970 0.81 CYP3A4 (0.55) ALOX15ALDH1A1HSD17B10MAPK1SMN1; SMN2
SCHEMBL3919358 0.79 CYP3A4 (0.59) ALOX15ALDH1A1HSD17B10MAPK1SMN1; SMN2
Hydrochloric Acid SCHEMBL29972242 0.79 CYP3A4 (0.52) ALOX15ALDH1A1HSD17B10MAPK1SMN1; SMN2
Hydrochloric Acid SCHEMBL8045536 0.79 CYP3A4 (0.52) ALOX15ALDH1A1HSD17B10MAPK1SMN1; SMN2
SCHEMBL5009700 0.79 ALOX15 (0.46) ALOX15ALDH1A1HSD17B10MAPK1SMN1; SMN2
SCHEMBL23229374 0.75 PTGER4 (0.41) ALOX15ALDH1A1HSD17B10MAPK1SMN1; SMN2
SCHEMBL872970 0.75 ALDH1A1 (0.43) ALOX15ALDH1A1HSD17B10MAPK1SMN1; SMN2
SCHEMBL3790991 0.75 ALDH1A1 (0.47) ALOX15ALDH1A1HSD17B10MAPK1SMN1; SMN2
SCHEMBL4843937 0.75 ALOX15 (0.43) ALOX15ALDH1A1HSD17B10MAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 569 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025242864-A1 DISCOLORING COMPOSITION FOR KERATIN FIBERS DYED WITH BLEACH-STABLE DIRECT DYES KAO CORPORATION (JP) 2025-11-27 WO claimed
EP-4408377-B1 COMPOSITION COMPRISING OXIDATIVE AND DIRECT DYES KAO CORP (JP) 2025-10-08 EP claimed
US-20240390243-A1 COMPOSITION COMPRISING OXIDATIVE AND DIRECT DYES KAO CORPORATION (JP) 2024-11-28 US claimed
US-20240390244-A1 COMPOSITION COMPRISING AN OXIDATIVE DYE SALT KAO CORPORATION (JP) 2024-11-28 US claimed
US-20240382394-A1 COMPOSITION COMPRISING AN OXIDATIVE DYE AND AMINE SALT KAO CORPORATION (JP) 2024-11-21 US claimed
EP-4408378-A1 COMPOSITION COMPRISING AN OXIDATIVE DYE SALT Kao Corporation (JP) 2024-08-07 EP claimed
EP-4408377-A2 COMPOSITION COMPRISING OXIDATIVE AND DIRECT DYES Kao Corporation (JP) 2024-08-07 EP claimed
CN-118119370-A Composition comprising an oxidation dye and a direct dye 花王株式会社 2024-05-31 CN claimed
CN-118055753-A Composition comprising an oxidation dye and an amine salt 花王株式会社 2024-05-17 CN claimed
CN-118043021-A Composition comprising oxidation dye salts 花王株式会社 2024-05-14 CN claimed
EP-1250910-A1 Hair dye composition GOLDWELL GmbH (DE) 2002-10-23 EP claimed
EP-1250909-A1 Hair dye composition GOLDWELL GmbH (DE) 2002-10-23 EP claimed
EP-1250912-A1 Hair dye composition GOLDWELL GmbH (DE) 2002-10-23 EP claimed
EP-1250908-A2 Hair dye GOLDWELL GmbH (DE) 2002-10-23 EP claimed
EP-1250911-A1 Hair dye composition GOLDWELL GmbH (DE) 2002-10-23 EP claimed
EP-0615743-B1 Hair dyeing composition GOLDWELL GMBH (DE) 1999-11-03 EP claimed
EP-0857477-B1 Hair dye GOLDWELL GMBH (DE) 1999-07-21 EP claimed
EP-0857477-A1 Hair dye GOLDWELL GmbH (DE) 1998-08-12 EP claimed
US-5421833-A 2-(2'-hydroxyethylamino0-5-aminotoluene and salts as developer and hydroxy compound as coupling agent mixable with peroxide compound immediately before use GOLDWELL AG (DE) 1995-06-06 US claimed
EP-0615743-A1 Hair dyeing composition GOLDWELL GmbH (DE) 1994-09-21 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240390243-A1 COMPOSITION COMPRISING OXIDATIVE AND DIRECT DYES KRT18, CYBA, CYBB ALOX15 1130/4885ALDH1A1 372/4885HSD17B10 267/4885
US-20240390244-A1 COMPOSITION COMPRISING AN OXIDATIVE DYE SALT CS, SDHA, MDH2 ALOX15 2758/4885ALDH1A1 231/4885HSD17B10 444/4885
US-20240382394-A1 COMPOSITION COMPRISING AN OXIDATIVE DYE AND AMINE SALT KRT18, AOC1, MUC1 ALOX15 1526/4885ALDH1A1 222/4885HSD17B10 1184/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.