Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.52 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | FABP3 | P05413 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169408 | 0.80 | SLC22A12 (0.43) | HTT | |
| SCHEMBL7613879 | 0.79 | ALDH1A1 (0.56) | MEN1KMT2ASMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL7864455 | 0.77 | BCAT2 (0.59) | BCAT2GPR52MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5180034 | 0.76 | BCAT2 (0.57) | BCAT2GPR52MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31521259 | 0.76 | BCAT2 (0.57) | BCAT2GPR52MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9448980 | 0.74 | CES2 (0.52) | GPR52MEN1KMT2ATSHRNPSR1 | |
| SCHEMBL9449288 | 0.74 | CES2 (0.52) | MEN1KMT2ATSHRRECQLNPSR1 | |
| SCHEMBL9448951 | 0.74 | ALDH1A1 (0.46) | MEN1KMT2ANPSR1HSP90AA1ALDH1A1 | |
| SCHEMBL9448877 | 0.74 | GPR52 (0.45) | GPR52MEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL28340415 | 0.74 | GPR52 (0.59) | BCAT2GPR52MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0466730-B1 | GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1993-07-21 | — | — | EP | disclosed |
| US-5220021-A | Geminal bisphosphonic acids and derivatives as anti-arthritic agents | THE UPJOHN COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| WO-1990012017-A1 | GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1990-10-18 | — | — | WO | disclosed |