Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | LDHB | P07195 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | NPY1R | P25929 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL954071 | 0.80 | ALDH1A1 (0.37) | CYP3A4ALDH1A1 | |
| SCHEMBL1552116 | 0.80 | OPRM1 (0.36) | OPRM1OPRK1 | |
| SCHEMBL8783202 | 0.78 | CA12 (0.30) | — | |
| SCHEMBL6853213 | 0.76 | ALDH1A1 (0.36) | RECQLALDH1A1 | |
| SCHEMBL10719494 | 0.75 | CYP2D6 (0.32) | CYP3A4 | |
| SCHEMBL8916645 | 0.70 | TAAR1 (0.33) | — | |
| SCHEMBL9327410 | 0.70 | OPRM1 (0.32) | CYP3A4CASP1RECQLOPRM1OPRK1 | |
| SCHEMBL10594549 | 0.68 | CYP3A4 (0.38) | CYP3A4ALDH1A1 | |
| SCHEMBL10664539 | 0.68 | OPRD1 (0.32) | OPRM1OPRK1 | |
| SCHEMBL18126 | 0.67 | HSD11B1 (0.36) | OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE34431-E | Macrocyclic oligomers containing spiro(bis)indane moieties | GENERAL ELECTRIC COMPANY (US) | 1993-11-02 | — | — | US | disclosed |
| EP-0326706-B1 | SPIRO(BIS)INDANE BIS-OXYPHTHALIC ACIDS AND FUNCTIONAL DERIVATIVES THEREOF | GENERAL ELECTRIC COMPANY (US) | 1992-03-11 | — | — | EP | disclosed |
| US-4980453-A | CONVERTED TO LINEAR POLYMERS | GENERAL ELECTRIC COMPANY (US) | 1990-12-25 | — | — | US | disclosed |
| US-4950727-A | Spiro(bis)indane polyamide and polyimide copolysiloxanes and method of preparation | GENERAL ELECTRIC COMPANY (US) | 1990-08-21 | — | — | US | disclosed |
| US-4864034-A | Spiro(bis)indane bis-oxyphthalic acids and functional derivatives thereof | GENERAL ELECTRIC COMPANY (US) | 1989-09-05 | — | — | US | disclosed |
| WO-1988006605-A1 | MACROCYCLIC OLIGOMERS CONTAINING SPIRO(BIS)INDANE MOIETIES | GENERAL ELECTRIC COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |