Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.69 |
| ▸ | MPO | P05164 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 2/20 | 0.65 |
| ▸ | HTR6 | P50406 | 1/20 | 0.63 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 5/20 | 0.61 |
| ▸ | DRD3 | P35462 | 5/20 | 0.61 |
| ▸ | DRD4 | P21917 | 3/20 | 0.61 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.61 |
| ▸ | HTR1B | P28222 | 2/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19140382 | 0.90 | HTR1A (0.65) | HTR1AHTR2AASIC3DRD2DRD3 | |
| SCHEMBL5172365 | 0.89 | HTR2A (0.74) | HTR1AHTR2AHTR6ASIC3DRD2 | |
| SCHEMBL17533456 | 0.87 | HTR1A (0.62) | HTR1AHTR2AASIC3DRD2DRD3 | |
| SCHEMBL20629330 | 0.85 | DRD2 (0.60) | HTR1AHTR2AASIC3DRD2DRD3 | |
| SCHEMBL5198374 | 0.82 | DRD3 (0.68) | HTR1ADRD2DRD3DRD4ADRA2A | |
| SCHEMBL4772684 | 0.82 | KDM4E (0.69) | HTR1AHTR2AHTR6DRD2DRD3 | |
| SCHEMBL13499605 | 0.81 | MPO (1.00) | HTR1AMPOHTR6DRD2DRD3 | |
| SCHEMBL947539 | 0.81 | MPO (0.71) | HTR1AMPOHTR2AHTR6DRD2 | |
| SCHEMBL947562 | 0.81 | MPO (0.71) | HTR1AMPOHTR2AHTR6ASIC3 | |
| SCHEMBL19252842 | 0.81 | MPO (0.71) | HTR1AMPOHTR6DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114642667-A | Pure 5-HT6Combination of receptor antagonists with acetylcholinesterase inhibitors | 苏文生命科学有限公司 | 2022-06-21 | — | — | CN | claimed |
| EP-3077375-B1 | PROCESS FOR LARGE SCALE PRODUCTION OF 1-[(2-BROMOPHENYL)SULFONYL]-5-METHOXY-3-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-INDOLE DIMESYLATE MONOHYDRATE | SUVEN LIFE SCIENCES LTD (IN) | 2017-07-19 | — | — | EP | claimed |
| US-9540321-B2 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesylate monohydrate | SUVEN LIFE SCIENCES LIMITED (IN) | 2017-01-10 | — | — | US | claimed |
| US-20160297759-A1 | PROCESS FOR LARGE SCALE PRODUCTION OF 1-[(2-BROMOPHENYL)SULFONYL]-5-METHOXY-3-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-INDOLE DIMESYLATE MONOHYDRATE | SUVEN LIFE SCIENCES LIMITED (IN) | 2016-10-13 | — | — | US | claimed |
| EP-3077375-A1 | PROCESS FOR LARGE SCALE PRODUCTION OF 1-[(2-BROMOPHENYL)SULFONYL]-5-METHOXY-3-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-INDOLE DIMESYLATE MONOHYDRATE | Suven Life Sciences Limited (IN) | 2016-10-12 | — | — | EP | claimed |
| WO-2015083179-A1 | PROCESS FOR LARGE SCALE PRODUCTION OF 1-[(2-BROMOPHENYL)SULFONYL]-5-METHOXY-3-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-INDOLE DIMESYLATE MONOHYDRATE | SUVEN LIFE SCIENCES LIMITED (IN) | 2015-06-11 | — | — | WO | claimed |
| EP-4069232-A1 | TREATING BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS IN DEMENTIA PATIENTS | Suven Life Sciences Limited (IN) | 2022-10-12 | — | — | EP | disclosed |
| CN-114642667-A | Pure 5-HT6Combination of receptor antagonists with acetylcholinesterase inhibitors | 苏文生命科学有限公司 | 2022-06-21 | — | — | CN | disclosed |
| EP-3180001-B1 | ACTIVE METABOLITE OF 1-[(2-BROMOPHENYL) SULFONYL]-5-METHOXY-3- [(4-METHYL-1-PIPERAZINYL) METHYL]-1H-INDOLE DIMESYLATE MONOHYDRATE AND DIMESYLATE DIHYDRATE SALT OF ACTIVE METABOLITE | SUVEN LIFE SCIENCES LTD (IN) | 2019-01-09 | — | — | EP | disclosed |
| EP-3077375-B1 | PROCESS FOR LARGE SCALE PRODUCTION OF 1-[(2-BROMOPHENYL)SULFONYL]-5-METHOXY-3-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-INDOLE DIMESYLATE MONOHYDRATE | SUVEN LIFE SCIENCES LTD (IN) | 2017-07-19 | — | — | EP | disclosed |
| EP-3077375-B1 | PROCESS FOR LARGE SCALE PRODUCTION OF 1-[(2-BROMOPHENYL)SULFONYL]-5-METHOXY-3-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-INDOLE DIMESYLATE MONOHYDRATE | SUVEN LIFE SCIENCES LTD (IN) | 2017-07-19 | — | — | EP | disclosed |
| US-9540321-B2 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesylate monohydrate | SUVEN LIFE SCIENCES LIMITED (IN) | 2017-01-10 | — | — | US | disclosed |
| US-9540321-B2 | Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole dimesylate monohydrate | SUVEN LIFE SCIENCES LIMITED (IN) | 2017-01-10 | — | — | US | disclosed |
| US-7781476-B2 | Serotonin and melatonergic ligands such as 10-(4-Methylpiperazin-1-ylmethyl)-5-thia-4b-aza-indeno[2,1-a]indene-5,5-dioxide, used for the treatment of psychological disorders, side effect reduction of antipsychotic drugs, neurodegenerative disorders, chemotherapy-induced vomiting and eating disorders | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-08-24 | — | — | US | disclosed |
| EP-1581492-B1 | N-ARYLSULFONYL-3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | SUVEN LIFE SCIENCES LTD (IN) | 2008-07-16 | — | — | EP | disclosed |
| US-20070142398-A1 | Tetracyclic 3-substituted indoles having serotonin receptor affinity | SUVEN LIFE SCIENCES LIMITED (IN) | 2007-06-21 | — | — | US | disclosed |
| EP-1581538-B1 | TETRACYCLIC 3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY | SUVEN LIFE SCIENCES LTD (IN) | 2007-02-28 | — | — | EP | disclosed |
| US-20060223890-A1 | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them | SUVEN LIFE SCIENCES LIMITED (IN) | 2006-10-05 | — | — | US | disclosed |
| EP-1581538-A1 | TETRACYCLIC 3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY | Suven Life Sciences Limited (IN) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004055026-A1 | TETRACYCLIC 3-SUBSTITUTED INDOLES HAVING SEROTONIN RECEPTOR AFFINITY | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142398-A1 | Tetracyclic 3-substituted indoles having serotonin receptor affinity | HTR3A, HTR3C, HTR3B | HTR1A 4/4885MPO 4733/4885HTR2A 8/4885 |
| US-20160297759-A1 | PROCESS FOR LARGE SCALE PRODUCTION OF 1-[(2-BROMOPHENYL)SULFONYL]-5-METHOXY-3-[(4-METHYL-1-PIPERAZINYL)METHYL]-1H-INDOLE DIMESYLATE MONOHYDRATE | HTR6, HTR2A, HTR5A | HTR1A 4/4885MPO 4264/4885HTR2A 2/4885 |
| US-20060223890-A1 | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them | HTR3A, HTR3C, HTR2C | HTR1A 6/4885MPO 4766/4885HTR2A 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.