SCHEMBL9475204

SCHEMBL9475204

CCN(CC)C(=O)n1cnc(NS(=O)(=O)c2ccccc2)n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LIMK1 P53667 1/20 0.44
LIMK2 P53671 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
NPSR1 Q6W5P4 1/20 0.43
TSHR P16473 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.41
SLC40A1 Q9NP59 2/20 0.41
KCNA5 P22460 1/20 0.41
GLA P06280 1/20 0.40
LMNA P02545 1/20 0.40
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9475473 0.76 L3MBTL1 (0.40) SMN1; SMN2NPSR1TSHRL3MBTL1LMNA
SCHEMBL9476966 0.75 ESR1 (0.40) SMN1; SMN2NPSR1L3MBTL1LMNAKMT2A
SCHEMBL9550226 0.74 LMNA (0.46) SMN1; SMN2TSHRL3MBTL1LMNA
SCHEMBL5376574 0.72 LMNA (0.40) SMN1; SMN2TSHRLMNAKMT2A
SCHEMBL8783273 0.71 L3MBTL1 (0.49) SMN1; SMN2NPSR1TSHRL3MBTL1LMNA
SCHEMBL9492475 0.71 MGLL (0.42) SMN1; SMN2NPSR1TSHRL3MBTL1LMNA
SCHEMBL9502987 0.68 ALDH1A1 (0.48) TSHRLMNAKMT2A
SCHEMBL9544526 0.68 DPP4 (0.40) SMN1; SMN2NPSR1LMNAKMT2A
SCHEMBL9015551 0.68 DPP4 (0.40) SMN1; SMN2NPSR1L3MBTL1LMNAKMT2A
SCHEMBL9015529 0.68 NPC1 (0.51) SMN1; SMN2NPSR1TSHRL3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5258361-A Antigrowth agents biological ROHM AND HAAS COMPANY (US) 1993-11-02 US claimed
US-5258361-A Antigrowth agents biological ROHM AND HAAS COMPANY (US) 1993-11-02 US disclosed