SCHEMBL9487356

SCHEMBL9487356

O=C([O-])c1cc(Br)cc(Br)c1O.[Na+]

nearest known ligand 0.64

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 known ✓ P23219 1/20 0.50
GABRA1 known ✓ P14867 1/20 0.46
GABRB1 known ✓ P18505 1/20 0.46
GABRA2 known ✓ P47869 1/20 0.46
GABRB2 known ✓ P47870 1/20 0.46
CA1 known ✓ P00915 1/20 0.39
CA2 known ✓ P00918 1/20 0.39
AKR1C4 P17516 2/20 0.64
AKR1C3 P42330 2/20 0.64
AKR1C2 P52895 2/20 0.64
AKR1C1 Q04828 2/20 0.64
CYP3A4 P08684 1/20 0.52
TSHR P16473 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
MEN1 O00255 3/20 0.50
HTT P42858 3/20 0.50
KMT2A Q03164 3/20 0.50
LMNA P02545 3/20 0.50
ALDH1A1 P00352 2/20 0.50
MAPT P10636 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL225014 0.96 AKR1C4 (0.64) AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4
Lithium Ion SCHEMBL9019696 0.96 AKR1C4 (0.64) AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4
Potassium Ion SCHEMBL9489269 0.96 AKR1C4 (0.64) AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4
SCHEMBL9398453 0.96 AKR1C4 (0.64) AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4
Water SCHEMBL9399160 0.94 AKR1C4 (0.62) AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4
SCHEMBL7182510 0.80 AKR1C4 (0.72) AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4
SCHEMBL29387062 0.78 AKR1C3 (1.00) AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4
SCHEMBL330545 0.78 AKR1C3 (1.00) AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4
SCHEMBL895511 0.77 AKR1C4 (0.67) AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4
SCHEMBL9398447 0.77 AKR1C3 (0.96) AKR1C4AKR1C3AKR1C2AKR1C1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5256514-A Toner compositions with halogenated salicylic acid charge enhancing additives XEROX CORPORATION (US) 1993-10-26 US disclosed
EP-0036534-B1 AN ORALLY ADMINISTRABLE DRUG FORM COMPRISING A BETA-LACTAM ANTIBIOTIC AND AN ADJUVANT INTERx RESEARCH CORPORATION (US) 1987-09-23 EP disclosed
EP-0035770-B1 AN ORALLY ADMINISTERED DRUG FORM COMPRISING A GLYCOSIDIC ANTIBIOTIC AND AN ADJUVANT INTERx RESEARCH CORPORATION (US) 1986-12-30 EP disclosed
EP-0037943-B1 PHARMACEUTICAL COMPOSITION FOR INTRARECTAL ADMINISTRATION, AND SUPPOSITORY PREPARED THEREFROM TEIJIN LIMITED (JP) 1985-08-14 EP disclosed
EP-0031561-B1 A RECTALLY ADMINISTERED SUPPOSITORY COMPRISING A DRUG AND AN ADJUVANT MERCK & CO. INC. (US) 1985-04-10 EP disclosed
US-4470980-A Method of increasing oral absorption of β-lactam antibiotics INTERX RESEARCH CORP. (US) 1984-09-11 US disclosed
US-4464363-A HYDROXY ARYL- OR HYDROXY ARALKYL ACIDS OR SALTS MERCK & CO., INC. (US) 1984-08-07 US disclosed
US-4406896-A ANTIBIOTICS, ACIDS, HYDROXY MERCK & CO., INC. (US) 1983-09-27 US disclosed
EP-0036534-A1 An orally administrable drug form comprising a beta-lactam antibiotic and an adjuvant INTERx RESEARCH CORPORATION (US) 1981-09-30 EP disclosed
EP-0036145-A1 An orally administered drug form comprising a polar bioactive agent and an adjuvant INTERx RESEARCH CORPORATION (US) 1981-09-23 EP disclosed
EP-0035770-A2 An orally administered drug form comprising a glycosidic antibiotic and an adjuvant INTERx RESEARCH CORPORATION (US) 1981-09-16 EP disclosed
EP-0031561-A2 A rectally administered suppository comprising a drug and an adjuvant MERCK & CO. INC. (US) 1981-07-08 EP disclosed