Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PARL | Q9H300 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9490445 | 0.91 | MMP2 (0.54) | MMP2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9490432 | 0.91 | MMP2 (0.54) | MMP2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9490689 | 0.91 | MMP2 (0.54) | MMP2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9489398 | 0.88 | MMP2 (0.56) | MMP2CYP3A4CYP2C9ALDH1A1POLB | |
| SCHEMBL9490990 | 0.84 | NPSR1 (0.53) | MMP2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| Acetic Acid SCHEMBL10461101 | 0.84 | MMP2 (0.53) | MMP2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9490595 | 0.83 | CTSG (0.44) | MMP2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL10459002 | 0.80 | L3MBTL1 (0.50) | ALDH1A1POLBMAPTPKMMEN1 | |
| SCHEMBL9697221 | 0.77 | KMT2A (0.53) | MMP2ALDH1A1POLBMAPTPKM | |
| SCHEMBL9699725 | 0.75 | NPSR1 (0.49) | MMP2ALDH1A1MAPTPKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266102-B1 | QUINOXALINONE DERIVATIVES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | claimed |
| US-4940708-A | 4-arylsulfonyl-3,4-dihydro-2(1H)-quinoxalinone-1-alkanoic acids, esters, and salts | PFIZER INC. (US) | 1990-07-10 | — | — | US | claimed |
| EP-0266102-A2 | Quinoxalinone derivatives | PFIZER INC. (US) | 1988-05-04 | — | — | EP | claimed |
| EP-0266102-B1 | QUINOXALINONE DERIVATIVES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| WO-1992005160-A1 | 4-ARYLSULFONYL-3,4-DIHYDRO-2(1H)-QUINOXALINONE-1-ALKANOIC ACIDS, ESTERS, AND SALTS | SARGES REINHARD (US) | 1992-04-02 | — | — | WO | disclosed |
| US-4940708-A | 4-arylsulfonyl-3,4-dihydro-2(1H)-quinoxalinone-1-alkanoic acids, esters, and salts | PFIZER INC. (US) | 1990-07-10 | — | — | US | disclosed |
| US-4940708-A | 4-arylsulfonyl-3,4-dihydro-2(1H)-quinoxalinone-1-alkanoic acids, esters, and salts | PFIZER INC. (US) | 1990-07-10 | — | — | US | disclosed |
| EP-0266102-A2 | Quinoxalinone derivatives | PFIZER INC. (US) | 1988-05-04 | — | — | EP | disclosed |