Sugi Predict

Sugi Predict / Compounds / SCHEMBL952008

SCHEMBL952008

SCHEMBL952008

O=Cc1ccc(C(F)(F)F)cc1Cl

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.55
▸ PDE2A O00408 4/20 0.44
▸ MAPT P10636 2/20 0.39
▸ POLB P06746 1/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ AHR P35869 1/20 0.39
▸ MEN1 O00255 1/20 0.38
▸ TSHR P16473 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ ATM Q13315 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ BACE1 P56817 1/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ DAO P14920 1/20 0.38
▸ MCL1 Q07820 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1571556 0.86 AR (0.51) TDP1
SCHEMBL132042 0.84 ALDH1A1 (0.41) TDP1PDE2AALDH1A1AHRMEN1
SCHEMBL12402929 0.82 PDE2A (0.40) TDP1PDE2AMAPTALDH1A1AHR
SCHEMBL29254639 0.82 PDE2A (0.46) PDE2AMAPTALDH1A1AHRBACE1
SCHEMBL6853258 0.81 POLB (0.42) TDP1MAPTPOLBALDH1A1MEN1
SCHEMBL9996684 0.80 PDE2A (0.44) PDE2AMAPTALDH1A1AHRBACE1
SCHEMBL4057549 0.80 TDP1 (0.55) TDP1MAPTPOLBALDH1A1MEN1
SCHEMBL9996686 0.80 PDE2A (0.49) PDE2AMAPTALDH1A1AHRBACE1
SCHEMBL1564067 0.78 XBP1 (0.41) TDP1MAPTPOLBALDH1A1MEN1
SCHEMBL875857 0.78 POLB (0.50) TDP1MAPTPOLBALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE48335-E1 Polymyxin derivatives as antimicrobial compounds MONASH UNIVERSITY (AU) 2020-12-01 — — US claimed
CN-106414480-B Polymyxin derivatives as antimicrobial compounds 莫纳什大学 2020-08-04 — — CN claimed
US-20170137469-A1 POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS MONASH UNIVERSITY (AU) 2017-05-18 — — US claimed
EP-3126376-A1 POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS Monash University (AU) 2017-02-08 — — EP claimed
WO-2015149131-A1 POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS MONASH UNIVERSITY (AU) 2015-10-08 — — WO claimed
US-20250388585-A1 PRMT5 INHIBITORS AND USES THEREOF GILEAD SCIENCES INC (US) 2025-12-25 — — US disclosed
US-12448388-B2 PRMT5 inhibitors and uses thereof GILEAD SCIENCES, INC. (US) 2025-10-21 — — US disclosed
US-20250099448-A1 HETEROCYCLIC COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 2025-03-27 — — US disclosed
CN-119306679-A Nitrogen-containing heterocyclic skeleton compound, preparation method and application thereof 中国科学院上海药物研究所 2025-01-14 — — CN disclosed
US-20240376110-A1 PRMT5 INHIBITORS AND USES THEREOF GILEAD SCIENCES, INC. 2024-11-14 — — US disclosed
WO-2024220917-A1 PRMT5 INHIBITORS AND USES THEREOF GILEAD SCIENCES, INC. (US) 2024-10-24 — — WO disclosed
US-12054484-B2 Substituted tetrahydropyrans as CCR2 modulators CHEMOCENTRYX, INC. (US) 2024-08-06 — — US disclosed
EP-0283173-A1 Pesticidal method using 2-phenylimidazole derivatives RHONE-POULENC AGRICULTURE LIMITED (GB) 1988-09-21 — — EP disclosed
EP-0247320-A2 5-Arylalkyl-4-alkoxy-2(5H)-furanones, intermediates and process for their preparation as well as their application as therapeutically active ingredients Dr. Willmar Schwabe GmbH & Co. (DE) 1987-12-02 — — EP disclosed
US-4689068-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1987-08-25 — — US disclosed
EP-0191394-A1 Isothioureas, process for their preparation and their use to combat undesirable plant growth BASF Aktiengesellschaft (DE) 1986-08-20 — — EP disclosed
US-4224340-A Anti-inflammatory compositions containing α-phenyl-N-phenylnitrone compounds WILLIAM H. RORER, INC. (US) 1980-09-23 — — US disclosed
US-4214003-A ANTIINFLAMMATORY AGENTS WILLIAM H. RORER, INC. (US) 1980-07-22 — — US disclosed
US-4197314-A WITH A DIPHENYL NITRONE WILLIAM H. RORER, INC. (US) 1980-04-08 — — US disclosed
US-4153722-A ANTIINFLAMMATORY, A-PHENYL-N-PHENYLNITRONE WILLIAM H. RORER, INC. (US) 1979-05-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250388585-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT1, PRMT5, PRMT6 TDP1 161/4885PDE2A 1640/4885MAPT 3947/4885
US-20240376110-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT5, PRMT1, PRMT9 TDP1 84/4885PDE2A 856/4885MAPT 2217/4885
US-12054484-B2 Substituted tetrahydropyrans as CCR2 modulators CCR2, CCR1, CCR5 TDP1 3313/4885PDE2A 2656/4885MAPT 3628/4885
US-12448388-B2 PRMT5 inhibitors and uses thereof PRMT5, PRMT1, PRMT9 TDP1 84/4885PDE2A 856/4885MAPT 2217/4885
US-20250099448-A1 HETEROCYCLIC COMPOUNDS OPRM1, CYP1A1, CYP3A4 TDP1 2538/4885PDE2A 1875/4885MAPT 2210/4885
US-20170137469-A1 POLYMYXIN DERIVATIVES AS ANTIMICROBIAL COMPOUNDS VIP, PEPD, NRDC TDP1 4681/4885PDE2A 4201/4885MAPT 4485/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.