Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9525680 | 0.91 | HTT (0.43) | ALDH1A1RAB9ABCHEHTTMAPT | |
| SCHEMBL9524812 | 0.86 | RAB9A (0.47) | HIF1ALMNAALDH1A1NPC1RAB9A | |
| SCHEMBL9524999 | 0.86 | RAB9A (0.44) | POLBLMNAALDH1A1NPC1RAB9A | |
| SCHEMBL9524816 | 0.82 | MEN1 (0.41) | NPSR1LMNAALDH1A1RAB9AHTT | |
| SCHEMBL9523603 | 0.81 | NPC1 (0.45) | HIF1ALMNAALDH1A1NPC1RAB9A | |
| SCHEMBL9525725 | 0.80 | KMT2A (0.49) | LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL9523908 | 0.80 | HPGD (0.46) | NPSR1TDP1HIF1ALMNAALDH1A1 | |
| SCHEMBL9527700 | 0.80 | DDX3X (0.44) | ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9527660 | 0.80 | ALDH1A1 (0.50) | CYP3A4ALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL9525178 | 0.80 | NPC1 (0.43) | POLBTAAR1TDP1CYP2C9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | claimed |