Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | MLYCD | O95822 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535755 | 0.87 | ALDH1A1 (0.52) | MAPTSMN1; SMN2MAPK1ALDH1A1TP53 | |
| SCHEMBL9536170 | 0.85 | MAPT (0.52) | MAPTSMN1; SMN2MAPK1ALDH1A1TP53 | |
| SCHEMBL9533937 | 0.85 | ALDH1A1 (0.50) | MAPTSMN1; SMN2MAPK1ALDH1A1TP53 | |
| SCHEMBL9537454 | 0.76 | GHSR (0.50) | NPC1SMN1; SMN2ALDH1A1TRPV1RAB9A | |
| SCHEMBL9533388 | 0.75 | TSHR (0.51) | MAPTNPC1ALDH1A1HTTRAB9A | |
| SCHEMBL5242546 | 0.75 | KMT2A (0.56) | SMN1; SMN2MAPK1HTTMEN1KMT2A | |
| SCHEMBL9533884 | 0.75 | KMT2A (0.59) | MAPTNPC1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL2787428 | 0.74 | MAPT (0.44) | MAPTNPC1SMN1; SMN2TP53NTRK1 | |
| SCHEMBL27495331 | 0.74 | KMT2A (0.55) | SMN1; SMN2MAPK1ALDH1A1HTTMEN1 | |
| SCHEMBL9535701 | 0.73 | KMT2A (0.54) | SMN1; SMN2MAPK1HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573883-A1 | Utilization of 3 substituted aryl-5-alkyl-isoxazole-4-carboxylic acid derivatives against endoparasites new 3-substituted aryl-5-alkyl-isoxazole-4-carboxylic acid derivatives and process for their preparation | BAYER AG (DE) | 1993-12-15 | — | — | EP | disclosed |