Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | IDH1 | O75874 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.48 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537454 | 0.91 | GHSR (0.50) | POLBGPBAR1ALDH1A1PTGS2CYP1A2 | |
| SCHEMBL9535755 | 0.90 | ALDH1A1 (0.52) | MAPTALDH1A1PTGS2TP53CYP1A2 | |
| SCHEMBL9533937 | 0.88 | ALDH1A1 (0.50) | MAPTKDM4EALDH1A1TP53MEN1 | |
| SCHEMBL9537105 | 0.85 | MAPT (0.56) | MAPTKDM4EGPBAR1ALDH1A1IDH1 | |
| SCHEMBL9533918 | 0.85 | MAPT (0.64) | MAPTALDH1A1TP53CYP1A2CYP2C9 | |
| SCHEMBL9534238 | 0.84 | POLB (0.45) | MAPTKDM4EPOLBGPBAR1IDH1 | |
| SCHEMBL9535442 | 0.81 | GPBAR1 (0.51) | MAPTKDM4EPOLBGPBAR1ALDH1A1 | |
| SCHEMBL9535701 | 0.78 | KMT2A (0.54) | POLBGPBAR1PTGS2TSHRMEN1 | |
| SCHEMBL9533388 | 0.78 | TSHR (0.51) | MAPTKDM4EALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL5242546 | 0.78 | KMT2A (0.56) | POLBPTGS2TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0573883-A1 | Utilization of 3 substituted aryl-5-alkyl-isoxazole-4-carboxylic acid derivatives against endoparasites new 3-substituted aryl-5-alkyl-isoxazole-4-carboxylic acid derivatives and process for their preparation | BAYER AG (DE) | 1993-12-15 | — | — | EP | disclosed |