Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.45 |
| ▸ | SLC18A2 | Q05940 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537087 | 0.85 | TSHR (0.54) | ACHEMEN1KMT2ASLC18A2ALDH1A1 | |
| SCHEMBL9540183 | 0.84 | ACHE (0.47) | ACHEMEN1KMT2ASLC18A2ALDH1A1 | |
| SCHEMBL10551946 | 0.81 | TSHR (0.52) | ACHEMEN1KMT2ASLC18A2ALDH1A1 | |
| SCHEMBL10550233 | 0.80 | ACHE (0.51) | ACHEMEN1KMT2ASLC18A2ALDH1A1 | |
| SCHEMBL9539084 | 0.79 | MEN1 (0.52) | MEN1KMT2ASLC6A9ALDH1A1HPGD | |
| SCHEMBL9539277 | 0.78 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1CYP3A4HPGD | |
| SCHEMBL9537082 | 0.77 | HTR2A (0.56) | MEN1KMT2ASLC18A2ALDH1A1CYP3A4 | |
| SCHEMBL10549103 | 0.76 | SLC18A2 (0.53) | ACHEMEN1KMT2ASLC18A2ALDH1A1 | |
| SCHEMBL9537145 | 0.75 | SLC6A9 (0.53) | MEN1KMT2ASLC6A9HPGDMAPT | |
| SCHEMBL9534954 | 0.75 | SMN1; SMN2 (0.52) | SLC6A9ALDH1A1CYP3A4HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | claimed |