Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9545376 | 0.78 | MAPT (0.30) | MAPTLMNASMN1; SMN2 | |
| SCHEMBL9545545 | 0.75 | POLB (0.38) | MAPTLMNASMN1; SMN2 | |
| SCHEMBL9545464 | 0.74 | ALDH1A1 (0.38) | MAPTLMNA | |
| SCHEMBL10746476 | 0.65 | CXCR2 (0.31) | LMNA | |
| SCHEMBL22577424 | 0.60 | ALDH1A1 (0.36) | MAPT | |
| SCHEMBL23388370 | 0.59 | TXNRD1 (0.41) | MAPTLMNASMN1; SMN2 | |
| SCHEMBL9214685 | 0.59 | CA2 (0.32) | — | |
| SCHEMBL778587 | 0.59 | LMNA (0.45) | MAPTLMNASMN1; SMN2 | |
| SCHEMBL20506736 | 0.57 | HSD11B1 (0.43) | MAPTLMNASMN1; SMN2 | |
| SCHEMBL16234260 | 0.57 | PSIP1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993021150-A2 | ARTHROPODICIDAL ARYL SULFONATES | DUNLENA PTY. LTD. (AU) | 1993-10-28 | — | — | WO | disclosed |