Fr-122047

Fr-122047

SCHEMBL9548128

COc1ccc(-c2nc(C(=O)N3CCN(C)CC3)sc2-c2ccc(OC)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 7/20 1.00
ALDH1A1 P00352 6/20 1.00
KDM4E B2RXH2 4/20 1.00
KMT2A Q03164 3/20 1.00
HPGD P15428 3/20 1.00
HSD17B10 Q99714 2/20 1.00
MEN1 O00255 2/20 1.00
CYP1A2 P05177 1/20 1.00
GLA P06280 1/20 1.00
CYP3A4 P08684 1/20 1.00
CYP2C9 P11712 1/20 1.00
TSHR P16473 1/20 1.00
PTGS1 P23219 1/20 1.00
TDP1 Q9NUW8 1/20 1.00
MAPT P10636 4/20 0.49
LMNA P02545 1/20 0.49
GAA P10253 1/20 0.49
HRH4 Q9H3N8 2/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fr-122047 SCHEMBL9548002 0.99 PTGS2 (0.98) PTGS2ALDH1A1KDM4EKMT2AHPGD
Fr-122047 SCHEMBL15531779 0.98 PTGS2 (0.95) PTGS2ALDH1A1KDM4EKMT2AHPGD
SCHEMBL9548056 0.90 ALDH1A1 (0.82) PTGS2ALDH1A1KDM4EKMT2AHPGD
SCHEMBL9548082 0.88 PTGS2 (0.79) PTGS2ALDH1A1KDM4EKMT2AHPGD
SCHEMBL9548039 0.88 PTGS2 (0.78) PTGS2ALDH1A1KDM4EKMT2AHPGD
SCHEMBL9548105 0.87 PTGS2 (0.77) PTGS2ALDH1A1KDM4EKMT2AHPGD
SCHEMBL9548091 0.87 ALDH1A1 (0.77) PTGS2ALDH1A1KDM4EKMT2AHPGD
Hydrochloric Acid SCHEMBL9547997 0.87 PTGS2 (0.76) PTGS2ALDH1A1KDM4EKMT2AHPGD
Hydrochloric Acid SCHEMBL9547994 0.86 PTGS2 (0.75) PTGS2ALDH1A1KDM4EKMT2AHPGD
SCHEMBL9548040 0.84 PTGS2 (0.72) PTGS2ALDH1A1KDM4EKMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4744663-A2 SKIN COMPOSITION Eaderm Co., Ltd. (JP) 2026-05-20 EP claimed
US-20260041336-A1 PLATELET REACTIVITY EXPRESSION SCORE PREDICTS CARDIOVASCULAR RISK NEW YORK UNIVERSITY (US) 2026-02-12 US claimed
US-12485107-B2 Methods for the prevention or treatment of cytokine storm BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) 2025-12-02 US claimed
US-12194020-B2 Reversing baldness through cannabinoid receptor activation POSTREL RICHARD (US) 2025-01-14 US claimed
CN-118079006-A Skin composition 国立大学法人东京医科齿科大学 2024-05-28 CN claimed
US-20230115675-A1 METHODS OF TREATING CANCER BROAD INST INC (US) 2023-04-13 US claimed
CN-115917324-A Methods of treating cancer 布罗德研究所有限公司 2023-04-04 CN claimed
EP-4111202-A1 METHODS OF TREATING CANCER The Broad Institute Inc. (US) 2023-01-04 EP claimed
US-20220331389-A1 SKIN COMPOSITION EADERM CO., LTD. (JP) 2022-10-20 US claimed
US-20220249434-A1 Reversal of Baldness in Men and Women through Cannabinoid Receptor Activation POSTREL RICHARD (US) 2022-08-11 US claimed
US-20220117884-A1 Methods and Compostitions for Enhancing the Viability of Microneedle Pores STINCHCOMB AUDRA LYNN (US) 2022-04-21 US claimed
EP-3978020-A1 SKIN COMPOSITION National University Corporation Tokyo Medical and Dental University (JP) 2022-04-06 EP claimed
US-5217971-A Anticoagulants, hypotensive agents, antiallergens and antiinflammatory agents FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-06-08 US claimed
EP-0377457-A1 Thiazole compounds, processes for the preparation thereof, and pharmaceutical composition comprising the same FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1990-07-11 EP claimed
EP-4744663-A2 SKIN COMPOSITION Eaderm Co., Ltd. (JP) 2026-05-20 EP disclosed
WO-2026090492-A1 TUMOR-ACTIVATED CELL ENGAGERS AND METHODS OF USE THEREOF Xilio Development, Inc. (US) 2026-04-30 WO disclosed
US-20260115302-A1 TUMOR-SPECIFIC CLEAVABLE LINKERS XILIO DEV INC (US) 2026-04-30 US disclosed
US-20220031631-A1 HIGH-PURITY PEG LIPIDS AND USES THEREOF MODERNATX, INC. (US) 2022-02-03 US disclosed
US-5217971-A Anticoagulants, hypotensive agents, antiallergens and antiinflammatory agents FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-06-08 US disclosed
EP-0377457-A1 Thiazole compounds, processes for the preparation thereof, and pharmaceutical composition comprising the same FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1990-07-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230115675-A1 METHODS OF TREATING CANCER SOD1, RNASE1, COXFA4L2 PTGS2 1378/4885ALDH1A1 727/4885KDM4E 3064/4885
US-20220031631-A1 HIGH-PURITY PEG LIPIDS AND USES THEREOF LIPA, HDLBP, PLTP PTGS2 2406/4885ALDH1A1 3836/4885KDM4E 2989/4885
US-12485107-B2 Methods for the prevention or treatment of cytokine storm TNF, PTGES2, IL2 PTGS2 4/4885ALDH1A1 953/4885KDM4E 3590/4885
US-20260115302-A1 TUMOR-SPECIFIC CLEAVABLE LINKERS SPPL2B, SPPL2A, CTSL PTGS2 2186/4885ALDH1A1 2254/4885KDM4E 2739/4885
US-20260041336-A1 PLATELET REACTIVITY EXPRESSION SCORE PREDICTS CARDIOVASCULAR RISK EPB41L2, MYLK2, RABL3 PTGS2 2609/4885ALDH1A1 3382/4885KDM4E 4178/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.