Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866590 | 0.86 | OPRM1 (0.43) | CHRM2CHRM1CHRM3GPR6SIGMAR1 | |
| SCHEMBL9565015 | 0.84 | CHRM2 (0.35) | CHRM2CHRM1CHRM3GPR6SIGMAR1 | |
| SCHEMBL9564838 | 0.77 | SSTR5 (0.43) | CHRM2CHRM1CHRM3SIGMAR1OPRM1 | |
| SCHEMBL9602879 | 0.76 | NOS2 (0.56) | L3MBTL1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9564782 | 0.73 | KCNH2 (0.45) | ROCK2ROCK1ALDH1A1LMNACYP2D6 | |
| SCHEMBL8207942 | 0.73 | KCNH2 (0.47) | CHRM2CHRM1CHRM3SIGMAR1OPRM1 | |
| SCHEMBL9564931 | 0.72 | ALDH1A1 (0.34) | OPRM1KDM4EALDH1A1LMNAPKM | |
| SCHEMBL9564775 | 0.72 | OPRM1 (0.48) | CHRM2CHRM1SIGMAR1OPRM1DRD4 | |
| SCHEMBL9565053 | 0.72 | KCNH2 (0.57) | CHRM2CHRM1CHRM3SIGMAR1OPRM1 | |
| SCHEMBL9565024 | 0.72 | LMNA (0.32) | LMNACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258380-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-11-02 | — | — | US | disclosed |
| US-5041448-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-20 | — | — | US | disclosed |
| EP-0206415-A2 | (4-Piperidinylmethyl and -hetero)purines | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-12-30 | — | — | EP | disclosed |