Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | GPR6 | P46095 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9564931 | 0.88 | ALDH1A1 (0.34) | OPRM1MEN1KMT2ALMNA | |
| SCHEMBL9866590 | 0.87 | OPRM1 (0.43) | CHRM2CHRM1CHRM3GPR6OPRM1 | |
| SCHEMBL9565024 | 0.87 | LMNA (0.32) | LMNACYP1A2CYP2C9CYP2C19WHR1 | |
| SCHEMBL9564925 | 0.84 | CHRM2 (0.38) | CHRM2CHRM1CHRM3GPR6OPRM1 | |
| SCHEMBL9602879 | 0.76 | NOS2 (0.56) | MEN1KMT2A | |
| SCHEMBL8207942 | 0.74 | KCNH2 (0.47) | CHRM2CHRM1CHRM3OPRM1SIGMAR1 | |
| SCHEMBL9564775 | 0.73 | OPRM1 (0.48) | CHRM2CHRM1OPRM1SIGMAR1CYP3A4 | |
| SCHEMBL9564838 | 0.73 | SSTR5 (0.43) | CHRM2CHRM1CHRM3OPRM1SIGMAR1 | |
| SCHEMBL9564782 | 0.73 | KCNH2 (0.45) | CYP3A4CYP2D6MEN1KMT2ALMNA | |
| SCHEMBL9565053 | 0.69 | KCNH2 (0.57) | CHRM2CHRM1CHRM3OPRM1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258380-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-11-02 | — | — | US | disclosed |
| US-5041448-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-20 | — | — | US | disclosed |
| EP-0206415-A2 | (4-Piperidinylmethyl and -hetero)purines | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-12-30 | — | — | EP | disclosed |