Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.33 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.33 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.33 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | GALK1 | P51570 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9587759 | 0.88 | ABCC9 (0.44) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9587106 | 0.75 | PPOX (0.40) | CYP11B2 | |
| SCHEMBL9588381 | 0.75 | CA2 (0.42) | TDP2PARP10 | |
| SCHEMBL30828314 | 0.72 | TDP2 (0.41) | TDP2MAPTPARP1PARP10GPR3 | |
| SCHEMBL4228062 | 0.70 | ALDH1A1 (0.42) | TDP2MAPTHSD17B10CES2KDM4E | |
| SCHEMBL9731044 | 0.68 | PDE2A (0.34) | ARMAPTHSD17B10CES2KDM4E | |
| SCHEMBL10838748 | 0.66 | PGR (0.47) | TDP2ARMAPTHSD17B10KMT2A | |
| SCHEMBL7766906 | 0.66 | ALDH1A1 (0.42) | MAPTHSD17B10KDM4E | |
| SCHEMBL12261410 | 0.66 | TDP2 (0.50) | TDP2PARP1PARP10NOTUMCYP11B2 | |
| SCHEMBL9565010 | 0.65 | CA1 (0.42) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5272170-A | Tetralones with pharmacological activity | J. URIACH & CIA., S.A. (ES) | 1993-12-21 | — | — | US | disclosed |
| US-5208246-A | Hypotensive, bronchodilator | J. URIACH & CIA. (ES) | 1993-05-04 | — | — | US | disclosed |
| EP-0489300-A2 | Tetralones with pharmacological activity | J. URIACH & CIA. S.A. (ES) | 1992-06-10 | — | — | EP | disclosed |