Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 3/20 | 0.35 |
| ▸ | DUT | P33316 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30106079 | 1.00 | FKBP1A (0.37) | FKBP1ATOP2ADUT | |
| SCHEMBL420855 | 1.00 | FKBP1A (0.37) | FKBP1ATOP2ADUT | |
| SCHEMBL420544 | 0.90 | FKBP1A (0.36) | FKBP1ATOP2ADUT | |
| SCHEMBL11970804 | 0.86 | TOP2A (0.38) | FKBP1ATOP2ADUT | |
| SCHEMBL19783450 | 0.84 | DUT (0.33) | DUT | |
| SCHEMBL7790340 | 0.78 | DUT (0.35) | DUT | |
| SCHEMBL15570491 | 0.77 | FKBP1A (0.32) | FKBP1A | |
| SCHEMBL8972926 | 0.76 | IRAK4 (0.35) | FKBP1ATOP2ADUT | |
| SCHEMBL20660408 | 0.76 | IRAK4 (0.35) | FKBP1ATOP2ADUT | |
| SCHEMBL8062803 | 0.76 | FKBP1A (0.33) | FKBP1ATOP2ADUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107474024-B | Glutaminase inhibitor and composition and application thereof | 北京赛林泰医药技术有限公司 | 2022-12-13 | — | — | CN | disclosed |
| US-8895582-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2014-11-25 | — | — | US | disclosed |
| US-8759374-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-20130053348-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | QIAN XIANGPING (US) | 2013-02-28 | — | — | US | disclosed |
| US-20120135964-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | QIAN XIANGPING (US) | 2012-05-31 | — | — | US | disclosed |
| US-8030495-B2 | Cyclopropyl pyrrolidine orexin receptor antagonists | MERCK SHARP & DOHME CORP. | 2011-10-04 | — | — | US | disclosed |
| US-20100152191-A1 | CYCLOPROPYL PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135964-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | MYLK, MYH2, MYH10 | FKBP1A 2736/4885TOP2A 262/4885DUT 2673/4885 |
| US-20100152191-A1 | CYCLOPROPYL PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS | HCRTR1, HCRTR2, OXTR | FKBP1A 44/4885TOP2A 4864/4885DUT 4831/4885 |
| US-20130053348-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | MYLK, MYH2, MYH10 | FKBP1A 2736/4885TOP2A 262/4885DUT 2673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.