SCHEMBL420544

SCHEMBL420544

CC(C)(C)[Si](C)(C)OCC1CCC(=O)CC1

nearest known ligand 0.36

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
FKBP1A P62942 1/20 0.36
DUT P33316 3/20 0.34
TOP2A P11388 4/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30106079 0.90 FKBP1A (0.37) FKBP1ADUTTOP2A
SCHEMBL420855 0.90 FKBP1A (0.37) FKBP1ADUTTOP2A
SCHEMBL9606663 0.90 FKBP1A (0.37) FKBP1ADUTTOP2A
SCHEMBL3400579 0.84 FKBP1A (0.33) FKBP1ADUTTOP2A
SCHEMBL7790340 0.84 DUT (0.35) DUT
SCHEMBL15570491 0.84 FKBP1A (0.32) FKBP1A
SCHEMBL8062803 0.82 FKBP1A (0.33) FKBP1ADUTTOP2A
SCHEMBL12632024 0.82 FKBP1A (0.33) FKBP1ADUTTOP2A
SCHEMBL31335101 0.82 FKBP1A (0.34) FKBP1A
SCHEMBL11970804 0.81 TOP2A (0.38) FKBP1ADUTTOP2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4727940-A1 DIHYDROPYRIMIDINE-2, 4 (1H, 3H) -DIONE-CONTAINING POLYCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREOF AND USE THEREOF Linkcure Therapeutics (KY) 2026-04-22 EP disclosed
WO-2025137605-A1 COMPOUNDS FOR TARGETED DEGRADATION OF PROTO-ONCOGENE TYROSINE PROTEIN KINASE RECEPTOR C4 THERAPEUTICS, INC. (US) 2025-06-26 WO disclosed
US-20250121073-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2025-04-17 US disclosed
US-20250084041-A1 ANTIMICROBIAL COMPOUNDS AND METHODS THE UNIVERSITY OF UTAH RESEARCH FOUNDATION 2025-03-13 US disclosed
WO-2024255810-A1 DIHYDROPYRIMIDINE-2, 4 (1H, 3H) -DIONE-CONTAINING POLYCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREOF AND USE THEREOF HANGZHOU GLUBIO PHARMACEUTICAL CO., LTD (CN) 2024-12-19 WO disclosed
US-12150995-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2024-11-26 US disclosed
EP-4457217-A1 ANTIMICROBIAL COMPOUNDS AND METHODS Curza Global LLC (US) 2024-11-06 EP disclosed
WO-2024173646-A1 CYCLIN-DEPENDENT KINASE DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. (US) 2024-08-22 WO disclosed
EP-4271664-A1 IRAK DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2023-11-08 EP disclosed
WO-2023193789-A1 WEE1 DEGRADING COMPOUNDS BEIJING NEOX BIOTECH LIMITED (CN) 2023-10-12 WO disclosed
WO-2010088167-A1 BRIDGED COMPOUNDS AS HIV INTEGRASE INHIBITORS MERCK SHARP & DOHME CORP. (US) 2010-08-05 WO disclosed
US-20090137597-A1 Novel quinoxalinone derivatives MSD K.K. (JP) 2009-05-28 US disclosed
US-7396953-B2 Angiogenesis inhibitors and pharmaceutical/cosmetic applications thereof GALDERMA RESEARCH & DEVELOPMENT (FR) 2008-07-08 US disclosed
US-7396953-B2 Angiogenesis inhibitors and pharmaceutical/cosmetic applications thereof GALDERMA RESEARCH & DEVELOPMENT (FR) 2008-07-08 US disclosed
US-7388010-B2 Quinoxalinone derivatives BANYU PHARMACEUTICAL CO., LTD. (JP) 2008-06-17 US disclosed
US-20070167519-A1 Novel Angiogenesis inhibitors and pharmaceutical/cosmetic applications thereof GALDERMA RESEARCH & DEVELOPMENT (FR) 2007-07-19 US disclosed
US-20070167519-A1 Novel Angiogenesis inhibitors and pharmaceutical/cosmetic applications thereof GALDERMA RESEARCH & DEVELOPMENT (FR) 2007-07-19 US disclosed
US-20070167519-A1 Novel Angiogenesis inhibitors and pharmaceutical/cosmetic applications thereof GALDERMA RESEARCH & DEVELOPMENT (FR) 2007-07-19 US disclosed
EP-1763500-A1 NOVEL ANGIOGENESIS INHIBITORS AND PHARMACEUTICAL AND COSMETIC USE THEREOF Galderma Research & Development, S.N.C. (FR) 2007-03-21 EP disclosed
WO-2006010859-A1 NOVEL ANGIOGENESIS INHIBITORS AND PHARMACEUTICAL AND COSMETIC USE THEREOF GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2006-02-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250121073-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 FKBP1A 2212/4885DUT 1964/4885TOP2A 3390/4885
US-20070167519-A1 Novel Angiogenesis inhibitors and pharmaceutical/cosmetic applications thereof FLT1, VEGFA, FGF1 FKBP1A 1180/4885DUT 1967/4885TOP2A 3125/4885
US-20090137597-A1 Novel quinoxalinone derivatives NDUFB1, NDUFB6, NDUFB7 FKBP1A 4460/4885DUT 3283/4885TOP2A 768/4885
US-12150995-B2 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK1 FKBP1A 2212/4885DUT 1964/4885TOP2A 3390/4885
US-20250084041-A1 ANTIMICROBIAL COMPOUNDS AND METHODS MPO, NISCH, RPN2 FKBP1A 3031/4885DUT 83/4885TOP2A 99/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.