Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9645259 | 0.80 | NPC1 (0.45) | LMNAPOLBMEN1TSHRKMT2A | |
| SCHEMBL9645288 | 0.70 | GAA (0.44) | LMNATSHRKDM4ESMN1; SMN2GAA | |
| SCHEMBL20100975 | 0.70 | POLB (0.34) | LMNABLMPOLBHTTKDM4E | |
| SCHEMBL9645470 | 0.69 | POLB (0.42) | LMNABLMPOLBHTTMEN1 | |
| SCHEMBL9645295 | 0.67 | GSK3A (0.40) | POLBGAAALDH1A1ELANE | |
| SCHEMBL7871541 | 0.65 | ALDH1A1 (0.34) | POLBMEN1TSHRKMT2AKDM4E | |
| SCHEMBL13206143 | 0.65 | LMNA (0.47) | LMNABLMHTTMEN1KMT2A | |
| SCHEMBL14045038 | 0.62 | MEN1 (0.56) | LMNABLMPOLBHTTMEN1 | |
| SCHEMBL12781874 | 0.62 | MAPT (0.70) | LMNABLMMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9645196 | 0.61 | LMNA (0.37) | LMNABLMHTTMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5086052-A | Antiarthritic, antiallergens, antiinflammatory agents; also for asthma and psoriasis | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| US-4970210-A | ENZYME INHIBITORS | ABBOTT LABORATORIES (US) | 1990-11-13 | — | — | US | disclosed |
| EP-0299449-A2 | Pyridazinone, triazinone and oxapyridazinone lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1989-01-18 | — | — | EP | disclosed |