Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.49 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL964597 | 0.83 | RXRA (0.39) | NR1H4RXRARXRB | |
| SCHEMBL14226712 | 0.83 | KAT6A (0.50) | AKR1C3AKR1C2CDK4CCND1 | |
| SCHEMBL2995452 | 0.81 | NR1H4 (0.74) | NR1H4FFAR1SMYD2S1PR4MCL1 | |
| SCHEMBL26054734 | 0.81 | CA12 (0.46) | NR1H4MCL1CDK4CCND1 | |
| SCHEMBL14226740 | 0.81 | KMO (0.60) | RXRARXRB | |
| SCHEMBL13611931 | 0.80 | NR1H4 (0.60) | NR1H4FFAR1SMYD2S1PR4CNR1 | |
| SCHEMBL28452076 | 0.80 | NR1H4 (0.59) | NR1H4FFAR1SMYD2S1PR4MCL1 | |
| SCHEMBL27959627 | 0.80 | NR1H4 (0.59) | NR1H4FFAR1SMYD2S1PR4MCL1 | |
| SCHEMBL3636122 | 0.80 | NR1H4 (0.56) | NR1H4FFAR1SMYD2S1PR4MCL1 | |
| SCHEMBL735164 | 0.79 | NR1H4 (0.55) | NR1H4FFAR1SMYD2S1PR4MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110245238-A1 | Novel Soluble 1,4 Benzodiazepine Compounds and Stable Salts Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-10-06 | — | — | US | claimed |
| US-20110009393-A1 | Novel Soluble 1,4 Benzodiazepine Compounds and Stable Salts Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-01-13 | — | — | US | claimed |
| US-7759338-B2 | Soluble 1,4 benzodiazepine compounds and stable salts thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-07-20 | — | — | US | claimed |
| EP-2152080-A1 | NOVEL SOLUBLE 1,4 BENZODIAZEPINE COMPOUNDS AND STABLE SALTS THEREOF | The Regents of the University of Michigan (US) | 2010-02-17 | — | — | EP | claimed |
| WO-2008133635-A1 | NOVEL SOLUBLE 1,4 BENZODIAZEPINE COMPOUNDS AND STABLE SALTS THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-11-06 | — | — | WO | claimed |
| US-20080064686-A1 | Novel soluble 1,4 benzodiazepine compounds and stable salts thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-03-13 | — | — | US | claimed |
| US-20120316105-A1 | Polymyxin Derivates Useful As Antibacterial Agents | PFIZER INC. | 2012-12-13 | — | — | US | disclosed |
| US-20110245238-A1 | Novel Soluble 1,4 Benzodiazepine Compounds and Stable Salts Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-10-06 | — | — | US | disclosed |
| US-20110009393-A1 | Novel Soluble 1,4 Benzodiazepine Compounds and Stable Salts Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-01-13 | — | — | US | disclosed |
| US-7759338-B2 | Soluble 1,4 benzodiazepine compounds and stable salts thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-07-20 | — | — | US | disclosed |
| EP-2152080-A1 | NOVEL SOLUBLE 1,4 BENZODIAZEPINE COMPOUNDS AND STABLE SALTS THEREOF | The Regents of the University of Michigan (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008133635-A1 | NOVEL SOLUBLE 1,4 BENZODIAZEPINE COMPOUNDS AND STABLE SALTS THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-11-06 | — | — | WO | disclosed |
| US-20080064686-A1 | Novel soluble 1,4 benzodiazepine compounds and stable salts thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245238-A1 | Novel Soluble 1,4 Benzodiazepine Compounds and Stable Salts Thereof | GABRA4, BAD, GABRA1 | NR1H4 507/4885FFAR1 264/4885SMYD2 4207/4885 |
| US-20080064686-A1 | Novel soluble 1,4 benzodiazepine compounds and stable salts thereof | GABRA4, BAD, GABRA1 | NR1H4 507/4885FFAR1 264/4885SMYD2 4207/4885 |
| US-20110009393-A1 | Novel Soluble 1,4 Benzodiazepine Compounds and Stable Salts Thereof | GABRA4, BAD, GABRA1 | NR1H4 507/4885FFAR1 264/4885SMYD2 4207/4885 |
| US-20120316105-A1 | Polymyxin Derivates Useful As Antibacterial Agents | NPEPPS, MDN1, PNKP | NR1H4 2305/4885FFAR1 3284/4885SMYD2 4102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.