Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY6 known ✓ | Q15077 | 9/20 | 0.71 |
| ▸ | P2RY2 known ✓ | P41231 | 2/20 | 0.53 |
| ▸ | P2RY4 known ✓ | P51582 | 1/20 | 0.53 |
| ▸ | P2RY14 | Q15391 | 4/20 | 0.71 |
| ▸ | NT5E | P21589 | 1/20 | 0.71 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | HBB | P68871 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11669053 | 0.92 | P2RY6 (0.74) | P2RY6P2RY14NT5EDNPH1TSHR | |
| SCHEMBL9682675 | 0.90 | P2RY6 (0.69) | P2RY6P2RY14NT5EDNPH1TSHR | |
| SCHEMBL9551479 | 0.89 | P2RY6 (0.77) | P2RY6P2RY14NT5EDNPH1TSHR | |
| SCHEMBL9683034 | 0.88 | P2RY6 (0.67) | P2RY6P2RY14NT5EDNPH1TSHR | |
| SCHEMBL668874 | 0.87 | P2RY6 (0.80) | P2RY6P2RY14NT5EDNPH1TSHR | |
| SCHEMBL27686864 | 0.87 | P2RY6 (0.80) | P2RY6P2RY14NT5EDNPH1TSHR | |
| SCHEMBL465109 | 0.87 | P2RY6 (0.80) | P2RY6P2RY14NT5EDNPH1TSHR | |
| Lithium Ion SCHEMBL29357540 | 0.86 | P2RY6 (0.79) | P2RY6P2RY14NT5EDNPH1TSHR | |
| SCHEMBL10932987 | 0.85 | P2RY6 (0.77) | P2RY6P2RY14NT5EDNPH1TSHR | |
| SCHEMBL9682454 | 0.85 | P2RY6 (0.62) | P2RY6P2RY14NT5EDNPH1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-1224393-A | — | — | None | — | — | JP | disclosed |
| EP-0500254-A1 | Process for the synthesis of nucleoside-5'-alkylphosphonates | TSUMURA & CO. (JP) | 1992-08-26 | — | — | EP | disclosed |
| JP-H01224393-A | NUCLEIC ACID DERIVATIVE AND CARCINOSTATIC AGENT CONTAINING SAID DERIVATIVE AS AN ACTIVE INGREDIENT | TSUMURA & CO | 1989-09-07 | — | — | JP | disclosed |