Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686849 | 0.81 | F10 (0.41) | MAPK1EPHX2TSHRMAPT | |
| SCHEMBL9687392 | 0.78 | CYP1A2 (0.46) | LMNAMAPK1ALOX5TSHRMEN1 | |
| SCHEMBL9688033 | 0.76 | HTT (0.49) | LMNAMAPK1TSHRMEN1KMT2A | |
| SCHEMBL9688037 | 0.75 | TSHR (0.49) | LMNATSHRMAPTKMT2A | |
| SCHEMBL9686935 | 0.73 | CNR1 (0.47) | ROCK2ROCK1MAPT | |
| SCHEMBL9280239 | 0.72 | RXFP1 (0.45) | TSHRMEN1MAPTKMT2AHTT | |
| SCHEMBL9164617 | 0.72 | NPC1 (0.51) | LMNAMAPK1TSHRMEN1MAPT | |
| SCHEMBL9278822 | 0.70 | RAB9A (0.46) | LMNAMAPK1TSHRMEN1MAPT | |
| SCHEMBL9026831 | 0.67 | IDO1 (0.45) | MEN1KMT2A | |
| SCHEMBL18887747 | 0.65 | LMNA (0.57) | LMNAMAPK1NLRP1EPHX2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |