Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 8/20 | 0.44 |
| ▸ | NPC1 | O15118 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9278822 | 0.88 | RAB9A (0.46) | RXFP1RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9164713 | 0.85 | MMP13 (0.48) | SMN1; SMN2ALDH1A1HTTMAPT | |
| SCHEMBL9164617 | 0.81 | NPC1 (0.51) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL9687941 | 0.79 | EZH2 (0.40) | NPC1SMN1; SMN2KMT2AHTTMEN1 | |
| SCHEMBL9688086 | 0.78 | HSD17B2 (0.46) | RXFP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL9687454 | 0.72 | MEN1 (0.39) | ALDH1A1KMT2AHTTMEN1MAPT | |
| SCHEMBL9687392 | 0.72 | CYP1A2 (0.46) | SMN1; SMN2ALDH1A1KMT2ATP53TSHR | |
| SCHEMBL9688033 | 0.72 | HTT (0.49) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL9687391 | 0.72 | HPGD (0.39) | RXFP1NPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL9688037 | 0.71 | TSHR (0.49) | RAB9ASMN1; SMN2ALDH1A1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459142-A | Autoimmune disease, atherosclerosis, antiischemic agents and nephritis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |