Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689969 | 0.88 | HDAC3 (0.39) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL9688900 | 0.85 | KDM4E (0.41) | HDAC6HDAC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL9690025 | 0.78 | PPARA (0.42) | HDAC6ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL9689482 | 0.76 | ALDH1A1 (0.34) | ALDH1A1RAB9AKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL9688550 | 0.76 | ALDH1A1 (0.42) | ALDH1A1RAB9ANPC1KMT2AKDM4E | |
| SCHEMBL9689963 | 0.73 | HDAC3 (0.43) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL9469004 | 0.71 | TDP1 (0.42) | ALDH1A1KMT2AKDM4E | |
| SCHEMBL9688521 | 0.70 | SIGMAR1 (0.38) | ALDH1A1RAB9AKMT2AKDM4EPRNP | |
| SCHEMBL8947138 | 0.68 | KMT2A (0.49) | HDAC6ALDH1A1KMT2AKDM4E | |
| SCHEMBL9689971 | 0.67 | ALDH1A1 (0.35) | ALDH1A1RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506011-A1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1992-09-30 | — | — | EP | disclosed |