Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.31 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.31 |
| ▸ | PRNP | P04156 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689971 | 0.89 | ALDH1A1 (0.35) | ALDH1A1KDM4ESMN1; SMN2MAP3K5PRNP | |
| SCHEMBL9689940 | 0.85 | TDP1 (0.40) | ALDH1A1KDM4ESMN1; SMN2GAAHPGD | |
| SCHEMBL9688895 | 0.84 | KDM4E (0.43) | ALDH1A1KDM4EMAP3K5PRNPHPGD | |
| SCHEMBL9690657 | 0.81 | NPSR1 (0.38) | MAPT | |
| SCHEMBL9690031 | 0.78 | TDP1 (0.40) | ALDH1A1KDM4ESMN1; SMN2GAAHPGD | |
| SCHEMBL9689487 | 0.76 | HDAC6 (0.43) | ALDH1A1KDM4EEIF4A3SMN1; SMN2MAP3K5 | |
| SCHEMBL9689975 | 0.72 | GPR139 (0.37) | ALDH1A1KDM4ESMN1; SMN2GAAMAP3K5 | |
| SCHEMBL9688515 | 0.71 | ALDH1A1 (0.38) | ALDH1A1KDM4ESMN1; SMN2GAAHPGD | |
| SCHEMBL9469004 | 0.70 | TDP1 (0.42) | ALDH1A1KDM4EGAAKMT2AMAPT | |
| SCHEMBL9689439 | 0.69 | KDM4E (0.45) | ALDH1A1KDM4ESMN1; SMN2MAP3K5PRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506011-A1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1992-09-30 | — | — | EP | disclosed |