Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 4/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | PTPRF | P10586 | 1/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | STK17B | O94768 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28873124 | 0.72 | PTPN1 (0.47) | BACE1PTPN1PTPRCPTPRFCDC25B | |
| SCHEMBL1354897 | 0.71 | OPRD1 (0.41) | OPRD1OPRK1KCNH2BACE1PTPN1 | |
| SCHEMBL982857 | 0.70 | SMN1; SMN2 (0.39) | PKMTDP1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL170839 | 0.67 | ALDH1A1 (0.39) | BACE1PTPN1PTPRCPTPRFCDC25B | |
| SCHEMBL29598333 | 0.67 | ALDH1A1 (0.39) | BACE1PTPN1PTPRCPTPRFCDC25B | |
| SCHEMBL7255969 | 0.67 | CTRC (0.39) | PKMTSHRKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL6919772 | 0.67 | GABRA1 (0.54) | OPRK1KCNH2TDP1KDM4EALDH1A1 | |
| SCHEMBL8191410 | 0.66 | BACE1 (0.44) | BACE1PTPN1PTPRCPTPRFCDC25B | |
| SCHEMBL2604370 | 0.66 | MAOB (0.43) | STK17BPKMTSHRALOX15TDP1 | |
| SCHEMBL29366641 | 0.66 | MAOB (0.43) | STK17BPKMTSHRALOX15TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2744797-A1 | DYRK1 INHIBITORS AND USES THEREOF | Diaxonhit (FR) | 2014-06-25 | — | — | EP | disclosed |
| WO-2013026806-A1 | DYRK1 INHIBITORS AND USES THEREOF | EXONHIT SA (FR) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013026942-A1 | TUBULIN BINDING AGENTS | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (IE) | 2013-02-28 | — | — | WO | disclosed |
| EP-0187524-B1 | A DIARYL BUTYRIC ACID DERIVATIVE AND THE PRODUCTION PROCESS THEREOF | SUNTORY LIMITED (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-4766116-A | NERVOUS SYSTEM DISORDERS | SUNTORY LIMITED (JP) | 1988-08-23 | — | — | US | disclosed |
| EP-0187524-A2 | A diaryl butyric acid derivative and the production process thereof | SUNTORY LIMITED (JP) | 1986-07-16 | — | — | EP | disclosed |