Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28235238 | 1.00 | ALDH1A1 (0.36) | ALDH1A1MAPTPTGS1TSHRSMN1; SMN2 | |
| SCHEMBL21403573 | 0.78 | ALDH1A1 (0.43) | ALDH1A1MAPTPTGS1SMN1; SMN2 | |
| SCHEMBL8769242 | 0.76 | ALDH1A1 (0.41) | ALDH1A1MAPTPTGS1 | |
| SCHEMBL504480 | 0.70 | ALDH1A1 (0.36) | ALDH1A1MAPTPTGS1TSHRSMN1; SMN2 | |
| SCHEMBL14935873 | 0.70 | ALDH1A1 (0.36) | ALDH1A1MAPTPTGS1TSHRSMN1; SMN2 | |
| SCHEMBL31196416 | 0.70 | ALOX15 (0.38) | ALDH1A1MAPTPTGS1SMN1; SMN2 | |
| SCHEMBL3109035 | 0.70 | ALDH1A1 (0.36) | ALDH1A1MAPTPTGS1 | |
| SCHEMBL253527 | 0.70 | — | — | |
| SCHEMBL725364 | 0.70 | — | — | |
| SCHEMBL905194 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240207429-A1 | LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME | WILMINGTON TRUST, NATIONAL ASSOCIATION | 2024-06-27 | — | — | US | disclosed |
| US-20240207418-A1 | LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME | PROFOUNDBIO US CO. | 2024-06-27 | — | — | US | disclosed |
| EP-4366777-A2 | LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME | PROFOUNDBIO US CO. (US) | 2024-05-15 | — | — | EP | disclosed |
| US-11793880-B2 | Conjugates of quaternized tubulysin compounds | SEAGEN INC. (US) | 2023-10-24 | — | — | US | disclosed |
| WO-2023280227-A2 | LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME | PROFOUNDBIO US CO. (US) | 2023-01-12 | — | — | WO | disclosed |
| US-20220226482-A1 | CONJUGATES OF QUATERNIZED TUBULYSIN COMPOUNDS | SEAGEN INC (US) | 2022-07-21 | — | — | US | disclosed |
| US-11229708-B2 | Conjugates of quaternized tubulysin compounds | SEAGEN INC. (US) | 2022-01-25 | — | — | US | disclosed |
| US-10226535-B2 | Auristatin compounds and conjugates thereof | MERSANA THERAPEUTICS, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| EP-2928503-B1 | CONJUGATES OF AURISTATIN COMPOUNDS | MERSANA THERAPEUTICS INC (US) | 2019-02-20 | — | — | EP | disclosed |
| US-20190015517-A1 | CONJUGATES OF QUATERNIZED TUBULYSIN COMPOUNDS | SEATTLE GENETICS, INC. (US) | 2019-01-17 | — | — | US | disclosed |
| US-20160310612-A1 | PEGYLATED DRUG-LINKERS FOR IMPROVED LIGAND-DRUG CONJUGATE PHARMACOKINETICS | SEATTLE GENETICS, INC. (US) | 2016-10-27 | — | — | US | disclosed |
| US-9463252-B2 | Auristatin drug linker conjugates | SEATTLE GENETICS, INC. (US) | 2016-10-11 | — | — | US | disclosed |
| CN-105764503-A | PEGylated drug-linkers for improved pharmacokinetics of ligand-drug conjugates | 西雅图基因公司 | 2016-07-13 | — | — | CN | disclosed |
| US-20150314008-A1 | AURISTATIN COMPOUNDS AND CONJUGATES THEREOF | MERSANA THERAPEUTICS, INC. | 2015-11-05 | — | — | US | disclosed |
| US-20140050746-A1 | AURISTATIN DRUG LINKER CONJUGATES | SEATTLE GENETICS, INC. (US) | 2014-02-20 | — | — | US | disclosed |
| US-8609105-B2 | Auristatin drug linker conjugates | SEATTLE GENETICS, INC. (US) | 2013-12-17 | — | — | US | disclosed |
| US-20110020343-A1 | AURISTATIN DRUG LINKER CONJUGATES | SEATTLE GENETICS, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-5849690-A | Anti-aggregatory peptides | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-15 | — | — | US | disclosed |
| US-5643872-A | ANTIAGGLOMERANTS FOR PLATELETS, ANTICOAGULANTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |
| US-5470849-A | Anticoagulants | SMITHKLINE BEECHAM CORP. (US) | 1995-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10226535-B2 | Auristatin compounds and conjugates thereof | PBRM1, AURKB, ILK | ALDH1A1 2684/4885MAPT 1644/4885PTGS1 3594/4885 |
| US-20240207418-A1 | LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME | PAICS, DHFR, CD44 | ALDH1A1 820/4885MAPT 457/4885PTGS1 4504/4885 |
| US-20220226482-A1 | CONJUGATES OF QUATERNIZED TUBULYSIN COMPOUNDS | LCK, UACA, TEKT1 | ALDH1A1 4270/4885MAPT 2747/4885PTGS1 4004/4885 |
| US-20110020343-A1 | AURISTATIN DRUG LINKER CONJUGATES | AURKA, AURKC, AURKB | ALDH1A1 1466/4885MAPT 686/4885PTGS1 4661/4885 |
| US-20140050746-A1 | AURISTATIN DRUG LINKER CONJUGATES | AURKA, AURKC, AURKB | ALDH1A1 1466/4885MAPT 686/4885PTGS1 4661/4885 |
| US-11229708-B2 | Conjugates of quaternized tubulysin compounds | LCK, UACA, TEKT1 | ALDH1A1 4270/4885MAPT 2747/4885PTGS1 4004/4885 |
| US-20190015517-A1 | CONJUGATES OF QUATERNIZED TUBULYSIN COMPOUNDS | LCK, UACA, TEKT1 | ALDH1A1 4270/4885MAPT 2747/4885PTGS1 4004/4885 |
| US-20240207429-A1 | LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME | PAICS, DHFR, CD44 | ALDH1A1 820/4885MAPT 457/4885PTGS1 4504/4885 |
| US-20150314008-A1 | AURISTATIN COMPOUNDS AND CONJUGATES THEREOF | PBRM1, BRWD1, BRDT | ALDH1A1 2233/4885MAPT 2861/4885PTGS1 3377/4885 |
| US-20160310612-A1 | PEGYLATED DRUG-LINKERS FOR IMPROVED LIGAND-DRUG CONJUGATE PHARMACOKINETICS | EGFR, HDGF, CD47 | ALDH1A1 1001/4885MAPT 2341/4885PTGS1 1098/4885 |
| US-11793880-B2 | Conjugates of quaternized tubulysin compounds | LCK, UACA, TEKT1 | ALDH1A1 4270/4885MAPT 2747/4885PTGS1 4004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.