SCHEMBL14935873

SCHEMBL14935873

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nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.36
MAPT P10636 2/20 0.36
PTGS1 P23219 1/20 0.36
KDM4E B2RXH2 3/20 0.34
MAPK1 P28482 1/20 0.34
HIF1A Q16665 1/20 0.34
THRB P10828 1/20 0.33
ALOX15 P16050 1/20 0.33
NFKB1 P19838 1/20 0.33
PTGS2 P35354 1/20 0.33
THPO P40225 1/20 0.33
RECQL P46063 1/20 0.33
BLM P54132 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
MTNR1A P48039 2/20 0.33
MTNR1B P49286 2/20 0.33
ADRA1A P35348 1/20 0.32
TSHR P16473 1/20 0.32
NPSR1 Q6W5P4 1/20 0.31
FOLH1 Q04609 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL504480 1.00 ALDH1A1 (0.36) ALDH1A1MAPTPTGS1KDM4EMAPK1
SCHEMBL21403573 0.78 ALDH1A1 (0.43) ALDH1A1MAPTPTGS1KDM4ETHRB
SCHEMBL8769242 0.76 ALDH1A1 (0.41) ALDH1A1MAPTPTGS1
N-Acetyl Penicillamine SCHEMBL4468919 0.74 MAPT (0.43) ALDH1A1MAPTPTGS1KDM4ETHRB
N-Acetyl Penicillamine SCHEMBL34351 0.74 MAPT (0.43) ALDH1A1MAPTPTGS1KDM4ETHRB
N-Acetyl Penicillamine SCHEMBL521764 0.74 MAPT (0.43) ALDH1A1MAPTPTGS1KDM4ETHRB
SCHEMBL30317213 0.71 ALDH1A1 (0.44) ALDH1A1MAPTPTGS1
SCHEMBL31668698 0.71 ALDH1A1 (0.44) ALDH1A1MAPTPTGS1
SCHEMBL3109035 0.70 ALDH1A1 (0.36) ALDH1A1MAPTPTGS1FOLH1
SCHEMBL31196416 0.70 ALOX15 (0.38) ALDH1A1MAPTPTGS1MAPK1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 190 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250302971-A1 Therapeutic Nanomaterials UNIV CONNECTICUT (US) 2025-10-02 US disclosed
US-20250302762-A1 NANOMATERIAL DELIVERY VEHICLE AND METHOD OF USE THEREOF UNIVERSITY OF CONNECTICUT (US) 2025-10-02 US disclosed
US-20250229081-A1 NANOMATERIAL COATED ELECTRODE AND METHODS OF USE THEREOF UNIVERSITY OF CONNECTICUT 2025-07-17 US disclosed
CN-120202010-A Ligand-oligonucleotide conjugates and linkers for use therewith 上海京新生物医药有限公司 2025-06-24 CN disclosed
US-20250084410-A1 INCORPORATION OF UNNATURAL NUCLEOTIDES AND METHODS THEREOF Synthorx, Inc. (US) 2025-03-13 US disclosed
US-20250066799-A1 UNNATURAL BASE PAIR COMPOSITIONS AND METHODS OF USE THE SCRIPPS RESEARCH INSTITUTE 2025-02-27 US disclosed
EP-4504732-A2 NANOMATERIAL DELIVERY VEHICLE AND METHOD OF USE THEREOF University of Connecticut (US) 2025-02-12 EP disclosed
US-12214043-B2 Therapeutic nanomaterials UNIVERSITY OF CONNECTICUT 2025-02-04 US disclosed
US-12173291-B2 Unnatural base pair compositions and methods of use THE SCRIPPS RESEARCH INSTITUTE (US) 2024-12-24 US disclosed
CN-118879592-A Unnatural base pair compositions and methods of use 斯克利普斯研究所 2024-11-01 CN disclosed
WO-2015153402-A1 PEPTIDE FRAGMENTS OF NETRIN-1 AND COMPOSITIONS AND METHODS THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-10-08 WO disclosed
US-9096684-B2 Peptidomimetic macrocycles AILERON THERAPEUTICS, INC. (US) 2015-08-04 US disclosed
US-20150183825-A1 TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. 2015-07-02 US disclosed
WO-2015051122-A2 WNT COMPOSITIONS AND METHODS FOR PURIFICATION THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2015-04-09 WO disclosed
US-8987414-B2 Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles AILERON THERAPEUTICS, INC. (US) 2015-03-24 US disclosed
US-20150051155-A1 PEPTIDOMIMETIC MACROCYCLES HOFFMANN-LA ROCHE, INC. 2015-02-19 US disclosed
US-8927500-B2 Peptidomimetic macrocycles AILERON THERAPEUTICS, INC. (US) 2015-01-06 US disclosed
US-20130274205-A1 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. 2013-10-17 US disclosed
US-20130210745-A1 TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2013-08-15 US disclosed
US-20130123169-A1 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2013-05-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250302971-A1 Therapeutic Nanomaterials TIE1, TEKT1, POLRMT ALDH1A1 3639/4885MAPT 194/4885PTGS1 3983/4885
US-20250302762-A1 NANOMATERIAL DELIVERY VEHICLE AND METHOD OF USE THEREOF JAK2, JAK1, CHMP4B ALDH1A1 1023/4885MAPT 605/4885PTGS1 2516/4885
US-12173291-B2 Unnatural base pair compositions and methods of use RNGTT, SPOUT1, NPEPPS ALDH1A1 4434/4885MAPT 3580/4885PTGS1 4650/4885
US-20250066799-A1 UNNATURAL BASE PAIR COMPOSITIONS AND METHODS OF USE RNGTT, SPOUT1, NPEPPS ALDH1A1 4434/4885MAPT 3580/4885PTGS1 4650/4885
US-20150051155-A1 PEPTIDOMIMETIC MACROCYCLES TP53, MDM2, MDM4 ALDH1A1 4570/4885MAPT 1649/4885PTGS1 3735/4885
US-20250084410-A1 INCORPORATION OF UNNATURAL NUCLEOTIDES AND METHODS THEREOF RNGTT, TRMT1, OSGEP ALDH1A1 3600/4885MAPT 3383/4885PTGS1 4371/4885
US-20130123169-A1 PEPTIDOMIMETIC MACROCYCLES GHRHR, GHSR, GHITM ALDH1A1 4843/4885MAPT 3661/4885PTGS1 2311/4885
US-12214043-B2 Therapeutic nanomaterials TIE1, TEKT1, POLRMT ALDH1A1 3639/4885MAPT 194/4885PTGS1 3983/4885
US-20130210745-A1 TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES IL33, TPR, CDC37 ALDH1A1 4459/4885MAPT 1935/4885PTGS1 1479/4885
US-20130274205-A1 PEPTIDOMIMETIC MACROCYCLES PROKR1, GLP1R, PROKR2 ALDH1A1 4764/4885MAPT 2765/4885PTGS1 3382/4885
US-20150183825-A1 TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES IL33, TPR, CDC37 ALDH1A1 4459/4885MAPT 1935/4885PTGS1 1479/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.