Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.42 |
| ▸ | ACP1 | P24666 | 6/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | USP1 | O94782 | 1/20 | 0.36 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9709743 | 0.88 | AGTR1 (0.41) | AGTR1AGTR2 | |
| SCHEMBL9709687 | 0.80 | CD38 (0.44) | AGTR1AGTR2ACP1 | |
| SCHEMBL9660639 | 0.76 | AGTR1 (0.38) | AGTR1AGTR2 | |
| SCHEMBL9709873 | 0.76 | AGTR1 (0.45) | AGTR1AGTR2ACP1NCF1PDE4A | |
| SCHEMBL9709740 | 0.75 | LTB4R2 (0.51) | AGTR1AGTR2ACP1PDE10A | |
| SCHEMBL9208929 | 0.72 | PDK2 (0.42) | — | |
| SCHEMBL9709757 | 0.72 | AGTR1 (0.52) | AGTR1AGTR2ACP1NCF1PDE4A | |
| SCHEMBL9265484 | 0.70 | PPARG (0.36) | AGTR1AGTR2 | |
| SCHEMBL9709741 | 0.68 | KDM4E (0.57) | AGTR1AGTR2ACP1 | |
| SCHEMBL9709750 | 0.67 | DHODH (0.59) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992022533-A1 | 4-AMINOQUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE UPJOHN COMPANY (US) | 1992-12-23 | — | — | WO | disclosed |