Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 5/20 | 0.36 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | SNCA | P37840 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9714819 | 0.81 | SNCA (0.38) | MAOAMAOBSLC6A4SNCASLC6A2 | |
| Hydrochloric Acid SCHEMBL9714652 | 0.77 | MEN1 (0.37) | MAOAMAOBSLC6A4SNCASLC6A2 | |
| SCHEMBL9714823 | 0.75 | MAOA (0.35) | MAOAMAOBSLC6A4L3MBTL1 | |
| Hydrochloric Acid SCHEMBL9714667 | 0.74 | SGMS2 (0.40) | MAOBTAAR1 | |
| Hydrochloric Acid SCHEMBL9714685 | 0.73 | MAOB (0.36) | MAOAMAOBSLC6A4SNCASLC6A2 | |
| Hydrochloric Acid SCHEMBL9714489 | 0.73 | SNCA (0.49) | MAOAMAOBSLC6A4SNCASLC6A2 | |
| Hydrochloric Acid SCHEMBL9714716 | 0.72 | SIGMAR1 (0.39) | MAOBTAAR1SIGMAR1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL5149449 | 0.72 | SNCA (0.52) | MAOASLC6A4SNCASLC6A2TAAR1 | |
| Hydrochloric Acid SCHEMBL3122079 | 0.71 | SNCA (0.42) | MAOASLC6A4SNCASLC6A2TAAR1 | |
| Hydrochloric Acid SCHEMBL9714788 | 0.70 | CTSB (0.37) | MAOASLC6A4SNCASLC6A2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166210-A | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5028615-A | Treatment of hypersensitivity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-07-02 | — | — | US | disclosed |
| US-4920133-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |