Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 8/20 | 0.60 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | USP47 | Q96K76 | 4/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11392906 | 0.87 | HSD17B1 (0.52) | USP7HSD17B1HSD17B2KDM4EPKM | |
| SCHEMBL7826596 | 0.81 | USP47 (0.52) | USP7HSD17B1HSD17B2KDM4EPKM | |
| SCHEMBL9724101 | 0.79 | HSD17B1 (0.48) | USP7HSD17B1HSD17B2KDM4EL3MBTL1 | |
| SCHEMBL11400591 | 0.75 | PKM (0.51) | USP7HSD17B1HSD17B2PKM | |
| SCHEMBL2681213 | 0.75 | USP7 (1.00) | USP7PADI4USP47 | |
| SCHEMBL9724080 | 0.73 | KDM4E (0.51) | USP7HSD17B1HSD17B2KDM4EPKM | |
| SCHEMBL13056224 | 0.72 | LMNA (0.40) | USP7HSD17B1HSD17B2KDM4EPKM | |
| SCHEMBL11392956 | 0.72 | HSD17B1 (0.52) | HSD17B1HSD17B2PKMPOLBRAB9A | |
| SCHEMBL11521691 | 0.71 | L3MBTL1 (0.68) | USP7HSD17B1HSD17B2KDM4EPKM | |
| SCHEMBL9724112 | 0.71 | ALOX5 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5158971-A | Antiallergens, antiinflammatory agents | LILLY INDUSTRIES LIMITED (GB) | 1992-10-27 | — | — | US | disclosed |
| EP-0459748-A2 | Thien-2-yl methylurea derivatives as leukotriene inhibitors | LILLY INDUSTRIES LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |