Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733666 | 0.78 | ALDH1A1 (0.38) | TDP1L3MBTL1ALDH1A1POLBTSHR | |
| SCHEMBL9733550 | 0.76 | ALDH1A1 (0.34) | TDP1L3MBTL1ALDH1A1POLBTSHR | |
| SCHEMBL9736930 | 0.74 | MEN1 (0.32) | ALDH1A1GAAMEN1KMT2AMAPT | |
| SCHEMBL9589012 | 0.71 | ALDH1A1 (0.36) | TDP1L3MBTL1ALDH1A1POLBTSHR | |
| SCHEMBL9733062 | 0.70 | HTR2A (0.38) | ALDH1A1POLBTSHROPRM1OPRD1 | |
| SCHEMBL9732996 | 0.68 | OPRM1 (0.44) | ALDH1A1POLBTSHROPRM1OPRD1 | |
| SCHEMBL9589616 | 0.68 | MAPK1 (0.36) | TDP1L3MBTL1ALDH1A1POLBTSHR | |
| SCHEMBL9736968 | 0.68 | IDO1 (0.38) | ALDH1A1POLBTSHRNPSR1 | |
| SCHEMBL9733605 | 0.68 | FAAH (0.37) | TDP1L3MBTL1ALDH1A1POLBTSHR | |
| SCHEMBL9143340 | 0.68 | ABCC9 (0.45) | ALDH1A1TSHRGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |