Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 13/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733259 | 0.87 | PGR (0.34) | POLBNSD2PGRBACE1CTSD | |
| SCHEMBL9733746 | 0.87 | PGR (0.34) | POLBNSD2PGRBACE1CASP3 | |
| SCHEMBL9732964 | 0.85 | DRD2 (0.35) | PGRBACE1ALK | |
| SCHEMBL9733975 | 0.84 | KCNH2 (0.37) | POLBPGRKMT2AALK | |
| SCHEMBL9733088 | 0.83 | MAPT (0.36) | PGRKMT2AALK | |
| SCHEMBL9733284 | 0.83 | HTR1A (0.37) | POLBNSD2PGRBACE1ALDH1A1 | |
| SCHEMBL9734001 | 0.83 | POLB (0.33) | POLBNSD2PGRBACE1CTSD | |
| SCHEMBL9734137 | 0.83 | BACE1 (0.35) | POLBNSD2PGRBACE1CASP3 | |
| SCHEMBL9733300 | 0.82 | MAOB (0.32) | PGRALK | |
| SCHEMBL9733001 | 0.82 | OTUD7B (0.35) | POLBPGRBACE1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |