Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CXCR5 | P32302 | 3/20 | 0.35 |
| ▸ | RARA | P10276 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733259 | 0.86 | PGR (0.34) | PGRPOLBMALT1 | |
| SCHEMBL9733300 | 0.85 | MAOB (0.32) | PGRALKMALT1 | |
| SCHEMBL9734356 | 0.84 | POLB (0.34) | KMT2APGRPOLBALK | |
| SCHEMBL9733746 | 0.84 | PGR (0.34) | PGRPOLBMALT1 | |
| SCHEMBL9733001 | 0.83 | OTUD7B (0.35) | KMT2AGAAMAPTPGRPOLB | |
| SCHEMBL9732964 | 0.82 | DRD2 (0.35) | MAPTPGRALK | |
| SCHEMBL9733088 | 0.81 | MAPT (0.36) | KCNH2KMT2AMAPTPGRHTT | |
| SCHEMBL9733284 | 0.81 | HTR1A (0.37) | KMT2APGRPOLB | |
| SCHEMBL8077021 | 0.80 | PDE4A (0.40) | KCNH2ALBNOTUMXDHSLC22A12 | |
| SCHEMBL9733106 | 0.78 | PGR (0.34) | PGRPOLBALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |