Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 4/20 | 0.31 |
| ▸ | CTSD | P07339 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.31 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.31 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.31 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733746 | 0.87 | PGR (0.34) | PGRPOLBNSD2CASP3BACE1 | |
| SCHEMBL9734356 | 0.87 | POLB (0.34) | PGRPOLBNSD2CASP3BACE1 | |
| SCHEMBL9733975 | 0.86 | KCNH2 (0.37) | PGRPOLBMALT1 | |
| SCHEMBL9732964 | 0.85 | DRD2 (0.35) | PGRBACE1 | |
| SCHEMBL9733300 | 0.84 | MAOB (0.32) | PGRMALT1 | |
| SCHEMBL9733001 | 0.84 | OTUD7B (0.35) | PGRPOLBBACE1 | |
| SCHEMBL9733088 | 0.83 | MAPT (0.36) | PGRABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9733284 | 0.83 | HTR1A (0.37) | PGRPOLBNSD2CASP3BACE1 | |
| SCHEMBL9733622 | 0.82 | POLB (0.35) | PGRPOLBNSD2CASP3BACE1 | |
| SCHEMBL9733106 | 0.80 | PGR (0.34) | PGRPOLBNSD2CASP3BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |