Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9732964 | 0.88 | DRD2 (0.35) | PGRALK | |
| SCHEMBL9733975 | 0.85 | KCNH2 (0.37) | PGRALKMALT1 | |
| SCHEMBL9733259 | 0.84 | PGR (0.34) | PGRMALT1 | |
| SCHEMBL9733001 | 0.83 | OTUD7B (0.35) | PGRLCKRETKDRLRRK2 | |
| SCHEMBL9733746 | 0.82 | PGR (0.34) | PGRMALT1 | |
| SCHEMBL9734356 | 0.82 | POLB (0.34) | PGRALK | |
| SCHEMBL7274143 | 0.82 | PDE4A (0.42) | MAOBMALT1 | |
| SCHEMBL9733088 | 0.78 | MAPT (0.36) | PGRALK | |
| SCHEMBL9733284 | 0.78 | HTR1A (0.37) | PGR | |
| SCHEMBL9733106 | 0.76 | PGR (0.34) | PGRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132307-A | TETRALIN COMPOUNDS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-21 | — | — | US | disclosed |
| EP-0368160-A1 | Tetralin derivatives | MERCK PATENT GmbH (DE) | 1990-05-16 | — | — | EP | disclosed |