Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735412 | 0.87 | ABCC9 (0.32) | LMNACYP2C19ABCC9 | |
| SCHEMBL9736968 | 0.87 | IDO1 (0.38) | ALDH1A1NPSR1TSHRSMN1; SMN2POLB | |
| SCHEMBL9736167 | 0.84 | ABCC9 (0.37) | LMNAL3MBTL1ALDH1A1SMN1; SMN2ABCC9 | |
| SCHEMBL8536595 | 0.84 | ABCC9 (0.49) | LMNACYP2C19ABCC9 | |
| SCHEMBL9738250 | 0.84 | OPRM1 (0.36) | TSHRSMN1; SMN2ABCC9 | |
| SCHEMBL9734831 | 0.84 | ALOX5 (0.37) | ALDH1A1TSHRSMN1; SMN2RAB9AKDM4E | |
| SCHEMBL9735276 | 0.83 | ABCC9 (0.32) | LMNACYP2C19ABCC9 | |
| SCHEMBL9735453 | 0.83 | TRPV1 (0.36) | LMNAALDH1A1NPSR1CYP3A4CYP2C19 | |
| SCHEMBL9796789 | 0.82 | ABCC9 (0.45) | LMNAL3MBTL1KCNE1KCNQ1ALDH1A1 | |
| SCHEMBL9796795 | 0.82 | ABCC9 (0.45) | LMNAL3MBTL1KCNE1KCNQ1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |