Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9738250 | 0.90 | OPRM1 (0.36) | ABCC9OPRM1SMN1; SMN2OPRD1TSHR | |
| SCHEMBL7269439 | 0.88 | ABCC9 (0.44) | ALOX5ABCC9KCNA5 | |
| SCHEMBL9736968 | 0.85 | IDO1 (0.38) | IDO1ABCC9SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL9735412 | 0.85 | ABCC9 (0.32) | ABCC9 | |
| SCHEMBL9735453 | 0.85 | TRPV1 (0.36) | OPRM1SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL9735244 | 0.84 | LMNA (0.36) | ABCC9RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9735276 | 0.83 | ABCC9 (0.32) | ABCC9OPRD1 | |
| SCHEMBL9736167 | 0.82 | ABCC9 (0.37) | ABCC9SMN1; SMN2ALDH1A1 | |
| SCHEMBL8536595 | 0.82 | ABCC9 (0.49) | ABCC9 | |
| SCHEMBL9735486 | 0.81 | ALOX5 (0.36) | ALOX5IDO1NPY5ROPRM1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |