Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735276 | 0.87 | ABCC9 (0.32) | TRPV1CYP1A2CYP2C19CYP2C9LMNA | |
| SCHEMBL8088757 | 0.86 | ABCC9 (0.41) | CYP1A2CYP2C19NPSR1MEN1KMT2A | |
| SCHEMBL9734831 | 0.85 | ALOX5 (0.37) | ALDH1A1TSHRSMN1; SMN2OPRM1 | |
| SCHEMBL9736968 | 0.83 | IDO1 (0.38) | NPSR1ALDH1A1TSHRSMN1; SMN2HTR2B | |
| SCHEMBL9735412 | 0.83 | ABCC9 (0.32) | TRPV1CYP1A2CYP2C19CYP2C9SLC10A2 | |
| SCHEMBL9738250 | 0.83 | OPRM1 (0.36) | TRPV1TSHRSMN1; SMN2HTR2COPRM1 | |
| SCHEMBL9735244 | 0.83 | LMNA (0.36) | CYP2C19NPSR1ALDH1A1LMNATP53 | |
| SCHEMBL9736167 | 0.81 | ABCC9 (0.37) | ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL8536595 | 0.81 | ABCC9 (0.49) | CYP1A2CYP2C19CYP2C9LMNACYP2D6 | |
| SCHEMBL9737119 | 0.77 | MAOA (0.40) | SIGMAR1CYP1A2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |