Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 5/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735453 | 0.87 | TRPV1 (0.36) | CYP1A2CYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL9735412 | 0.83 | ABCC9 (0.32) | ABCC9ABCB1ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9736968 | 0.83 | IDO1 (0.38) | ABCC9 | |
| SCHEMBL9734831 | 0.83 | ALOX5 (0.37) | ABCC9OPRD1 | |
| SCHEMBL8536595 | 0.83 | ABCC9 (0.49) | ABCC9ABCB1ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9735244 | 0.83 | LMNA (0.36) | ABCC9CYP2C19LMNA | |
| SCHEMBL9738250 | 0.81 | OPRM1 (0.36) | ABCC9OPRD1TRPV1 | |
| SCHEMBL9736167 | 0.81 | ABCC9 (0.37) | ABCC9LMNA | |
| SCHEMBL9732909 | 0.77 | OPRD1 (0.35) | OPRD1 | |
| SCHEMBL9735348 | 0.75 | ABCC9 (0.42) | ABCC9ABCB1ABCC8KCNJ11KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |
| EP-0415065-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |