Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | CASP6 | P55212 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP4 | P49662 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CASP9 | P55211 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735249 | 0.85 | POLB (0.33) | KMT2AMEN1POLBMALT1KDM4E | |
| SCHEMBL10757454 | 0.84 | CASP6 (0.40) | NR1H4KMT2AMEN1CASP6POLB | |
| SCHEMBL9201653 | 0.82 | NR1H4 (0.37) | NR1H4KMT2AMEN1CASP6POLB | |
| SCHEMBL9735603 | 0.82 | PDE4A (0.44) | MALT1CASP3 | |
| SCHEMBL9735371 | 0.82 | ALDH1A1 (0.37) | POLBRAB9AKDM4ECASP3ALDH1A1 | |
| SCHEMBL9735261 | 0.82 | NR1H4 (0.38) | NR1H4KMT2AMEN1CASP6POLB | |
| SCHEMBL8120777 | 0.81 | CASP6 (0.37) | NR1H4KMT2AMEN1CASP6POLB | |
| SCHEMBL9204440 | 0.80 | NR1H4 (0.35) | NR1H4KMT2AMEN1CASP6POLB | |
| SCHEMBL8123714 | 0.78 | CASP6 (0.37) | NR1H4KMT2AMEN1CASP6POLB | |
| SCHEMBL9735809 | 0.77 | MEN1 (0.35) | KMT2AMEN1CASP6POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130322-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-07-14 | — | — | US | disclosed |